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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_72317
http://purl.obolibrary.org/obo/CHEBI_72317
|
|---|---|
| Preferred Name | cabozantinib |
| Synonyms |
XL 184
N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
BMS-907351
C28H24FN3O5
BMS 907351
XL184
XL-184
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | cabozantinib
|
|---|---|
| label | cabozantinib
|
| DBSynonym |
xl-184
cabozantinib s-malate
|
| Definition | A dicarboxylic acid diamide that is N-phenyl-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide in which the hydrogen at position 4 on the phenyl ring is substituted by a (6,7-dimethoxyquinolin-4-yl)oxy group. A multi-tyrosine kinase inhibitor, used (as its malate salt) for the treatment of progressive, metastatic, medullary thyroid cancer.
Cabozantinib was approved in 2012 and is a non-specific tyrosine kinase inhibitor. It is marketed as COMETRIQ?, which is indicated for the treatment of metastatic medullary thyroid cancer. It s label includes a black box warning of gastrointestinal perforations, fistulas, and hemorrhage.
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| has pharmacological target | |
| type | |
| has role | |
| InChIKey | InChIKey=ONIQOQHATWINJY-UHFFFAOYSA-N
|
| is metabolised by | |
| blocks | |
| Synonym |
XL 184
N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
BMS-907351
C28H24FN3O5
BMS 907351
XL184
XL-184
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|
| xref |
CiteXplore:22585997
CiteXplore:21314233
CiteXplore:23319797
RxList:http://www.rxlist.com/cometriq-drug.htm
CiteXplore:23248244
CiteXplore:23292795
KEGG DRUG:D10062
Patent:WO2012109510
Drugs.com:http://www.drugs.com/mtm/cabozantinib.html
ChEMBL:1477987
Wikipedia:http://en.wikipedia.org/wiki/Cabozantinib
CiteXplore:23319867
CiteXplore:23319755
CiteXplore:20127563
CiteXplore:23104465
CiteXplore:21862995
CiteXplore:21860001
CiteXplore:23337763
ChEBI:72317
CiteXplore:21606412
CiteXplore:23375349
Wikipedia:Cabozantinib
CASRN:849217-68-1
CiteXplore:21613405
CiteXplore:23335077
CiteXplore:21926191
CiteXplore:23169517
CiteXplore:23292257
CiteXplore:21460789
Reaxys:18631644
CiteXplore:22146228
CiteXplore:23337762
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|
| CASRN | 849217-68-1
|
| prefixIRI | obo2:CHEBI_72317
|
| SMILES | COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
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| may interact with | |
| InChI | InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
|
| DBBrand | cometriq
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |