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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_72297
http://purl.obolibrary.org/obo/CHEBI_72297
|
|---|---|
| Preferred Name | lomitapide |
| Synonyms |
lomitapide
BMS 201038
N-(2,2,2-trifluoroethyl)-9-{4-[4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidin-1-yl]butyl}-9H-fluorene-9-carboxamide
C39H37F6N3O2
AEGR 733
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | lomitapide
|
|---|---|
| label | lomitapide
|
| DBSynonym |
bms-201038-04
aegr-773
bms 201038
|
| ATCCode | C10AX12
|
| Definition | A carboxamide obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia.
Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid.
|
| DBSalt | lomitapide mesylate
|
| has pharmacological target | |
| inhibits | |
| type | |
| has role | |
| InChIKey | InChIKey=MBBCVAKAJPKAKM-UHFFFAOYSA-N
|
| is metabolised by | |
| blocks | |
| AHFScode | 24:06.92
|
| Synonym | lomitapide
BMS 201038
N-(2,2,2-trifluoroethyl)-9-{4-[4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidin-1-yl]butyl}-9H-fluorene-9-carboxamide
C39H37F6N3O2
AEGR 733
|
| xref |
Patent:US2012035204
Patent:US2010273829
RxList:http://www.rxlist.com/juxtapid-drug.htm
ChEMBL:382991
Reaxys:13754976
National Drug Code Directory:76431-110-01
CiteXplore:20127562
Drugs.com:http://www.drugs.com/juxtapid.html
Wikipedia:http://en.wikipedia.org/wiki/Lomitapide
CiteXplore:23122768
CiteXplore:22963620
Patent:US2008161279
Patent:US2003162788
Wikipedia:Lomitapide
Patent:US2011288064
KEGG DRUG:D09637
CiteXplore:23147576
ChEBI:72297
CiteXplore:21846156
Patent:US2012071458
Patent:US2011288110
CASRN:182431-12-5
CiteXplore:23122767
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| CASRN | 202914-84-9
|
| prefixIRI | obo2:CHEBI_72297
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| SMILES | FC(F)(F)CNC(=O)C1(CCCCN2CCC(CC2)NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c2ccccc2-c2ccccc12
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| may interact with |
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|
| InChI | InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
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| DBBrand | juxtapid
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| subClassOf |
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