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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_71253
http://purl.obolibrary.org/obo/CHEBI_71253
|
|---|---|
| Preferred Name | asenapine |
| Synonyms |
rac-(3aR,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
asenapine
(3aRS,12bRS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
(+-)-asenapine
trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole
C21H20ClNO5
asenapina
(2Z)-but-2-enedioic acid; 9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.0^{2,6}.0^{7,12}]octadeca-1(14),7(12),8,10,15,17-hexaene
asenapinum
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | asenapine
|
|---|---|
| label | asenapine
|
| DBSynonym | org-5222
|
| ATCCode | N05AH05
|
| Definition | A racemate consisting of equal amounts of (R,R)- and (S,S)-asenapine. Used as its maleate salt for the acute treatment of schizophrenia and acute treatment of manic or mixed episodes associated with bipolar I disorder with or without psychotic features.
Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine also belongs to the dibenzo-oxepino pyrrole class. It is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use. FDA approved on August 13, 2009.
|
| has effect |
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| DBSalt | asenapine maleate
|
| has pharmacological target | |
| inhibits | |
| type | |
| has role | |
| InChIKey | InChIKey=GMDCDXMAFMEDAG-BTJKTKAUSA-N
|
| is metabolised by | |
| blocks |
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| AHFScode | 28:16.08.04
|
| Synonym | rac-(3aR,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
asenapine
(3aRS,12bRS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
(+-)-asenapine
trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole
C21H20ClNO5
asenapina
(2Z)-but-2-enedioic acid; 9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.0^{2,6}.0^{7,12}]octadeca-1(14),7(12),8,10,15,17-hexaene
asenapinum
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|
| xref |
RxList:http://www.rxlist.com/saphris-drug.htm
ChemSpider:10128588
PubChem Compound:11954293
CiteXplore:21628604
Patent:WO2012040845
CASRN:65576-45-6
CiteXplore:23121334
CiteXplore:22182459
CiteXplore:21474903
CiteXplore:22362425
Drugs.com:http://www.drugs.com/mtm/asenapine.html
CiteXplore:22454251
Patent:US2006084692
CiteXplore:21875607
CiteXplore:21557265
National Drug Code Directory:0052-2139-03
CiteXplore:22849428
CiteXplore:22198451
CiteXplore:22700206
CiteXplore:23095277
CiteXplore:22726414
CiteXplore:22900950
ChEBI:71253
CiteXplore:22344545
Patent:US2005119248
CiteXplore:22936407
Wikipedia:Asenapine
Reaxys:3654823
Patent:WO2012038975
Patent:US2006229352
CiteXplore:22494521
CiteXplore:22877962
Patent:WO2012123325
CiteXplore:22896826
CiteXplore:22156709
PubChem Substance:17397151
CiteXplore:22198448
CiteXplore:21755540
Wikipedia:http://en.wikipedia.org/wiki/Asenapine
CiteXplore:22868059
CiteXplore:22745558
CiteXplore:22332980
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| CASRN | 65576-45-6
|
| prefixIRI | obo2:CHEBI_71253
|
| SMILES | OC(=O)\C=C/C(O)=O.CN1CC2C(C1)C1=C(OC3=CC=CC=C23)C=CC(Cl)=C1
|
| may interact with |
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| InChI | InChI=1S/C17H16ClNO.C4H4O4/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;5-3(6)1-2-4(7)8/h2-8,14-15H,9-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
|
| DBBrand |
saphris
sycrest
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| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |