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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_71013
http://purl.obolibrary.org/obo/CHEBI_71013
|
|---|---|
| Preferred Name | perampanel |
| Synonyms |
Fycompa
ER-155055-90
C23H15N3O
perampanelum
3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one
perampanel
E 2007
2-(6'-oxo-1'-phenyl-1',6'-dihydro-2,3'-bipyridin-5'-yl)benzonitrile
E2007
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | perampanel
|
|---|---|
| label | perampanel
|
| DBSynonym |
er-155055-90
e-2007
|
| ATCCode | N03AX22
|
| Definition | A member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy.
Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa? and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning of serious or life-threatening behavioral and psychiatric reactions in patients taking Fycompa?.
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| has pharmacological target | |
| induces | |
| type | |
| has role | |
| InChIKey | InChIKey=PRMWGUBFXWROHD-UHFFFAOYSA-N
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| is metabolised by | |
| blocks | |
| Synonym |
Fycompa
ER-155055-90
C23H15N3O
perampanelum
3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one
perampanel
E 2007
2-(6'-oxo-1'-phenyl-1',6'-dihydro-2,3'-bipyridin-5'-yl)benzonitrile
E2007
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|
| xref |
CiteXplore:22222634
CASRN:380917-97-5
CiteXplore:22905878
Wikipedia:Perampanel
CiteXplore:22776828
CiteXplore:22433907
CiteXplore:21686307
KEGG DRUG:D08964
CiteXplore:22650169
CiteXplore:21883097
CiteXplore:21635236
National Drug Code Directory:62856-282-30
Patent:US2009088574
RxList:http://www.rxlist.com/fycompa-drug.htm
Patent:EP1875912
Wikipedia:http://en.wikipedia.org/wiki/Perampanel
ChEBI:71013
CiteXplore:22913800
Patent:WO2006107859
CiteXplore:22788917
CiteXplore:22517103
Reaxys:11343244
Patent:US2008108603
CiteXplore:22161845
CiteXplore:22905857
ChEMBL:785974
CiteXplore:23093905
CiteXplore:23114872
Patent:WO2008111590
Drugs.com:http://www.drugs.com/mtm/perampanel.html
CiteXplore:22843280
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| CASRN | 380917-97-5
|
| prefixIRI | obo2:CHEBI_71013
|
| SMILES | O=c1c(cc(cn1-c1ccccc1)-c1ccccn1)-c1ccccc1C#N
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| may interact with | |
| InChI | InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H
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| DBBrand | fycompa
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| subClassOf |
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