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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_6909
http://purl.obolibrary.org/obo/CHEBI_6909
|
|---|---|
| Preferred Name | metronidazole |
| Synonyms |
2-methyl-5-nitroimidazole-1-ethanol
2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole
2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol
1-(beta-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-oxyethyl)-2-methyl-5-nitroimidazole
metronidazole
C6H9N3O3
1-(beta-ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole
metronidazol
1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole
2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethan-1-ol
2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole
metronidazolum
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | metronidazole
|
|---|---|
| label | metronidazole
|
| DBSynonym |
metronidazole benzoate
metronidazole in plastic container
metronidazol
metronidazolo
metronidazole hcl
methronidazole
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|
| ATCCode |
J01XD01
P01AB01
A01AB17
G01AF01
D06BX01
|
| Definition | Imidazole substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
|
| altId | CHEBI:63636
|
| has effect |
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|
| has pharmacological target | |
| inhibits | |
| type | |
| binds | |
| has role | |
| InChIKey | InChIKey=VAOCPAMSLUNLGC-UHFFFAOYSA-N
|
| is metabolised by | |
| AHFScode |
84:04.04
84:04.92
08:30.92
|
| Synonym |
2-methyl-5-nitroimidazole-1-ethanol
2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole
2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol
1-(beta-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-oxyethyl)-2-methyl-5-nitroimidazole
metronidazole
C6H9N3O3
1-(beta-ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole
metronidazol
1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole
2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethan-1-ol
2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole
metronidazolum
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|
| xref |
NIST Chemistry WebBook:443-48-1
Drugs Product Database (DPD):649074
CiteXplore:19485831
CiteXplore:14702395
KEGG DRUG:D00409
DrugBank:DB00916
Beilstein:611683
CiteXplore:16304169
PharmGKB:PA450484
CiteXplore:22252819
CiteXplore:15739364
ChEBI:6909
Drugs.com:http://www.drugs.com/metronidazole.html
PubChem Substance:46508911
ChemSpider:4029
PubChem Compound:4173
Wikipedia:Metronidazole
CiteXplore:16901452
CASRN:443-48-1
RxList:http://www.rxlist.com/cgi/generic/metron.htm
CiteXplore:11906111
National Drug Code Directory:0299-3835-45
CiteXplore:22226009
Patent:US2944061
Reaxys:611683
Wikipedia:http://en.wikipedia.org/wiki/Metronidazole
CiteXplore:18397330
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|
| CASRN | 443-48-1
|
| prefixIRI | obo2:CHEBI_6909
|
| related with | |
| SMILES |
Cc1ncc(n1CCO)[N+]([O-])=O
CC1=NC=C(N1CCO)[N+]([O-])=O
|
| may interact with |
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|
| DBname | metronidazole
|
| InChI | InChI=1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3
|
| DBBrand |
trikacide
flagesol
eumin
trichocide
nalox
trikamon
metronidaz
trichopal
elyzol
metromidol
protostat
trimeks
meronidal
trichopol
metrolyl
mexibol
tricom
tricowas b
acromona
noritate
orvagil
metrogel
anagiardil
efloran
wagitran
bexon
deflamon-wirkstoff
vagilen
tricocet
danizol
metro cream
klion
monagyl
trikojol
zadstat
deflamon
metrolotion
giatricol
gineflavir
atrivyl
trivazol
apo-metronidazole
metro i.v.
trikozol
flagil
cont
tricho-gynaedron
entizol
fossyol
flagyl i.v.
flagyl
flagemona
bayer 5360
vagimid
satric
trichazol
flagyl er
tricho cordes
clont
nidagel
klont
metric 21
monasin
rathimed
neo-tric
vertisal
flegyl
takimetol
metro i.v. in plastic container
metrotop
metrogel-vaginal
arilin
novonidazol
nida
metrolag
trichex
sanatrichom
metrocream
trichomol
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|
| subClassOf |
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|---|---|---|---|---|
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