The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Id	http://purl.obolibrary.org/obo/CHEBI_68584 http://purl.obolibrary.org/obo/CHEBI_68584
Preferred Name	ezogabine
Synonyms	Ethyl 2-amino-4-((p-fluorobenzyl)amino)carbanilate N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester N-(2-Amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester D-23129 ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate ethyl N-(2-amino-4-{[(4-fluorophenyl)methyl]amino}phenyl)carbamate retigabine Potiga C16H18FN3O2
Type	http://www.w3.org/2002/07/owl#Class

prefLabel	ezogabine
label	ezogabine
DBSynonym	d23129 d-23129 retigabine ezg rtg
ATCCode	N03AX21
Definition	Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients with refractory epilepsy. FDA approved in June 10, 2011 under the name of ezogabine. A substituted aniline that is benzene-1,2,4-triamine bearing ethoxycarbonyl and 4-fluorobenzyl substituents at positions N-1 and N-4 respectively. An anticonvulsant used to treat seizures associated with epilepsy in adults.
inhibits	http://purl.obolibrary.org/obo/dinto_2496
type	http://www.w3.org/2002/07/owl#Class
has role	http://purl.obolibrary.org/obo/CHEBI_50510 http://purl.obolibrary.org/obo/CHEBI_35623
InChIKey	InChIKey=PCOBBVZJEWWZFR-UHFFFAOYSA-N
is metabolised by	http://purl.obolibrary.org/obo/dinto_1892 http://purl.obolibrary.org/obo/dinto_0265 http://purl.obolibrary.org/obo/dinto_0270 http://purl.obolibrary.org/obo/dinto_0276 http://purl.obolibrary.org/obo/dinto_2047
AHFScode	28:12.92
Synonym	Ethyl 2-amino-4-((p-fluorobenzyl)amino)carbanilate N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester N-(2-Amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester D-23129 ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate ethyl N-(2-amino-4-{[(4-fluorophenyl)methyl]amino}phenyl)carbamate retigabine Potiga C16H18FN3O2 See more See less
xref	PubChem Compound:121892 Patent:US2012053238 Reaxys:8072099 KEGG DRUG:D09569 Wikipedia:http://en.wikipedia.org/wiki/Retigabine CiteXplore:22991134 Patent:US6348486 Drugs.com:http://www.drugs.com/mtm/ezogabine.html CASRN:150812-12-7 PharmGKB:PA144997862 PubChem Substance:10239851 ChEMBL:161945 Patent:US5384330 Patent:WO2007090409 ChEBI:68584 BindingDB:50143558 Patent:US2002111379 Patent:US2002015730 Patent:WO2011012659 ChemSpider:108740 RxList:http://www.rxlist.com/potiga-drug.htm KEGG COMPOUND:C13826 National Drug Code Directory:0173-0814-59 Patent:US2002183395 Wikipedia:Ezogabine See more See less
CASRN	150812-12-7
prefixIRI	obo2:CHEBI_68584
related with	http://purl.obolibrary.org/obo/dinto_3118 http://purl.obolibrary.org/obo/dinto_3115 http://purl.obolibrary.org/obo/dinto_3116 http://purl.obolibrary.org/obo/dinto_4068
SMILES	CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N CCOC(=O)NC1=C(N)C=C(NCC2=CC=C(F)C=C2)C=C1
may interact with	http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/dinto_DB00904 http://purl.obolibrary.org/obo/CHEBI_6367 http://purl.obolibrary.org/obo/CHEBI_3387
InChI	InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21)
DBBrand	potiga
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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