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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_681850
http://purl.obolibrary.org/obo/CHEBI_681850
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|---|---|
| Preferred Name | conivaptan |
| Synonyms |
4'-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1H)-yl)carbonyl)-2-biphenylcarboxanilide
N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide
Conivaptan
C32H26N4O2
conivaptan
N-[4-({4-methyl-3,5,9-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),2(6),3,11,13-pentaen-9-yl}carbonyl)phenyl]-2-phenylbenzamide
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | conivaptan
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|---|---|
| label | conivaptan
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| DBSynonym |
conivaptan hydrochloride
ym 087
ym-087
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| ATCCode | C03XA02
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| Definition | The amide resulting from the formal condensation of 4-[(biphenyl-2-ylcarbonyl)amino]benzoic acid with the benzazepine nitrogen of 2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2. It is used as its hydrochloride salt for the treatment of hyponatraemia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH).
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| has effect |
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| has pharmacological target | |
| inhibits | |
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| has role | |
| InChIKey | InChIKey=IKENVDNFQMCRTR-UHFFFAOYSA-N
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| is metabolised by | |
| blocks | |
| Synonym | 4'-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1H)-yl)carbonyl)-2-biphenylcarboxanilide
N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide
Conivaptan
C32H26N4O2
conivaptan
N-[4-({4-methyl-3,5,9-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),2(6),3,11,13-pentaen-9-yl}carbonyl)phenyl]-2-phenylbenzamide
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| xref |
Beilstein:8658375
ChEMBL:20070106
ChemSpider:133239
Wikipedia:Conivaptan
IUPHAR:2203
DrugBank:DB00872
CASRN:210101-16-9
PharmGKB:PA164742939
PubChem Compound:151171
PubChem Substance:46504533
Guide To Pharmacology:2203
ChEBI:681850
Drugs.com:http://www.drugs.com/cdi/conivaptan.html
KEGG DRUG:D07748
Wikipedia:http://en.wikipedia.org/wiki/Conivaptan
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| CASRN | 210101-16-9
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| prefixIRI | obo2:CHEBI_681850
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| SMILES |
CC1=NC2=C(CCN(C(=O)C3=CC=C(NC(=O)C4=CC=CC=C4C4=CC=CC=C4)C=C3)C3=CC=CC=C23)N1
Cc1nc2CCN(C(=O)c3ccc(NC(=O)c4ccccc4-c4ccccc4)cc3)c3ccccc3-c2[nH]1
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| may interact with |
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| DBname | conivaptan
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| InChI | InChI=1S/C32H26N4O2/c1-21-33-28-19-20-36(29-14-8-7-13-27(29)30(28)34-21)32(38)23-15-17-24(18-16-23)35-31(37)26-12-6-5-11-25(26)22-9-3-2-4-10-22/h2-18H,19-20H2,1H3,(H,33,34)(H,35,37)
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| DBBrand | vaprisol
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| subClassOf |
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