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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_681569
http://purl.obolibrary.org/obo/CHEBI_681569
|
|---|---|
| Preferred Name | clofarabine |
| Synonyms |
2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
clofarabinum
clofarabina
2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine
2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine
(2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
C10H11ClFN5O3
CAFdA
clofarabine
Cl-F-Ara-A
(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | clofarabine
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|---|---|
| label | clofarabine
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| ATCCode | L01BB06
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| Definition | A purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metabolite, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia.
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| has effect |
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| has pharmacological target | |
| inhibits | |
| type | |
| has role | |
| InChIKey | InChIKey=WDDPHFBMKLOVOX-AYQXTPAHSA-N
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| is metabolised by | |
| Synonym |
2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
clofarabinum
clofarabina
2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine
2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine
(2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
C10H11ClFN5O3
CAFdA
clofarabine
Cl-F-Ara-A
(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
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| xref |
KEGG DRUG:D03546
Beilstein:4882539
ChEBI:681569
ChEMBL:19929004
Drugs.com:http://www.drugs.com/cdi/clofarabine.html
RxList:http://www.rxlist.com/cgi/generic3/clofarabine.htm
DrugBank:DB00631
National Drug Code Directory:58468-0100-1
PubChem Compound:119182
PubChem Substance:46504968
Wikipedia:http://en.wikipedia.org/wiki/Clofarabine
ChemSpider:106472
Wikipedia:Clofarabine
CASRN:123318-82-1
PharmGKB:PA164754863
PDB:CFB
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| CASRN | 123318-82-1
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| prefixIRI | obo2:CHEBI_681569
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| is transported by | |
| related with | |
| SMILES |
[H][C@]1(F)[C@H](O)[C@@H](CO)O[C@H]1N1C=NC2=C(N)N=C(Cl)N=C12
Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F
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| may interact with | |
| DBname | clofarabine
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| InChI | InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
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| DBBrand |
clolar
evoltra
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| subClassOf |
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