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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_66919
http://purl.obolibrary.org/obo/CHEBI_66919
|
|---|---|
| Preferred Name | ruxolitinib |
| Synonyms |
C17H18N6
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
INCB018424
ruxolitinib
(3R)-3-cyclopentyl-3-(4-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazol-1-yl)propanenitrile
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | ruxolitinib
|
|---|---|
| label | ruxolitinib
|
| DBSynonym |
incb424
incb018424
incb 18424
|
| ATCCode | L01XE18
|
| Definition | Ruxolitinib is a janus-associated kinase inhibitor indicated to treat bone marrow cancer, specifically intermediate or high-risk myelofibrosis. FDA approved on November 16, 2011.
A pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis.
|
| DBSalt | ruxolitinib phosphate
|
| has pharmacological target | |
| inhibits | |
| type | |
| has role | |
| InChIKey | InChIKey=HFNKQEVNSGCOJV-OAHLLOKOSA-N
|
| is metabolised by | |
| AHFScode | 10:00
|
| Synonym |
C17H18N6
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
INCB018424
ruxolitinib
(3R)-3-cyclopentyl-3-(4-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazol-1-yl)propanenitrile
|
| xref |
CiteXplore:22474318
Drugs.com:http://www.drugs.com/mtm/ruxolitinib.html
CASRN:941678-49-5
CiteXplore:22544377
CiteXplore:22227528
CiteXplore:22375971
Patent:US2008312258
National Drug Code Directory:50881-025-60
Wikipedia:Ruxolitinib
CiteXplore:21926964
CiteXplore:22422826
Reaxys:18703668
CiteXplore:22281165
CiteXplore:22718840
CiteXplore:22830345
CiteXplore:22034658
CiteXplore:21602517
RxList:http://www.rxlist.com/jakafi-drug.htm
CiteXplore:21919691
Patent:US2010190981
CiteXplore:22279053
ChEBI:66919
CiteXplore:22375970
ChEMBL:1253572
Wikipedia:http://en.wikipedia.org/wiki/Ruxolitinib
KEGG DRUG:D09959
CiteXplore:22399854
See more
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|
| CASRN | 941678-49-5
|
| prefixIRI | obo2:CHEBI_66919
|
| SMILES |
N#CC[C@H](C1CCCC1)N1C=C(C=N1)C1=C2C=CNC2=NC=N1
N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
|
| may interact with | |
| InChI | InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1
|
| DBBrand |
jakavi
jakafi
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |