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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_66903
http://purl.obolibrary.org/obo/CHEBI_66903
|
|---|---|
| Preferred Name | vismodegib |
| Synonyms |
2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-(methylsulfonyl)benzamide
C19H14Cl2N2O3S
vismodegib
vismodegibum
Erivedge
2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-methanesulfonylbenzamide
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | vismodegib
|
|---|---|
| label | vismodegib
|
| DBSynonym |
rg-3616
hedgehog antagonist gdc-0449
gdc-0449
|
| ATCCode | L01XX43
|
| Definition | A benzamide obtained by formal condensation between the carboxy group of 2-chloro-4-(methylsulfonyl)benzoic acid and the anilino group of 4-chloro-3-(pyridin-2-yl)aniline. Used for the treatment metastatic basal cell carcinoma.
Vismodegib inhibits the hedgehog signalling pathway and is indicated for treatment of adult basal cell carcinoma. FDA approved on Jan 30, 2012.
|
| has pharmacological target | |
| inhibits | |
| type | |
| has role | |
| InChIKey |
InChIKey=BPQMGSKTAYIVFO-UHFFFAOYNA-N
InChIKey=BPQMGSKTAYIVFO-UHFFFAOYSA-N
|
| is metabolised by | |
| blocks | |
| AHFScode | 10:00
|
| Synonym |
2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-(methylsulfonyl)benzamide
C19H14Cl2N2O3S
vismodegib
vismodegibum
Erivedge
2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-methanesulfonylbenzamide
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|
| xref |
CiteXplore:22777303
CiteXplore:21753154
CiteXplore:22718857
CiteXplore:22844657
National Drug Code Directory:50242-140-01
Drugs.com:http://www.drugs.com/mtm/vismodegib.html
Reaxys:12532124
Wikipedia:http://en.wikipedia.org/wiki/Vismodegib
ChEMBL:560092
CiteXplore:22805146
CiteXplore:22679179
CiteXplore:22788238
RxList:http://www.rxlist.com/erivedge-drug.htm
Wikipedia:Vismodegib
PharmGKB:PA166048558
CiteXplore:22489352
CiteXplore:21610148
CASRN:879085-55-9
CiteXplore:22653209
ChEBI:66903
CiteXplore:22458643
CiteXplore:22670904
CiteXplore:22670903
CiteXplore:21602311
CiteXplore:22618984
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|
| CASRN | 879085-55-9
|
| prefixIRI | obo2:CHEBI_66903
|
| is transported by | |
| is substrate of | |
| SMILES |
CS(=O)(=O)C1=CC(Cl)=C(C=C1)C(=O)NC1=CC=C(Cl)C(=C1)C1=CC=CC=N1
CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(c2)-c2ccccn2)c(Cl)c1
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| may interact with | |
| InChI | InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
InChI=1/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
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| DBBrand | erivedge
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |