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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
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| Id | http://purl.obolibrary.org/obo/CHEBI_6427
http://purl.obolibrary.org/obo/CHEBI_6427
|
|---|---|
| Preferred Name | leuprolide |
| Synonyms |
pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt
C59H84N16O12
leuprorelina
leuprorelinum
5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
(D-Leu(6),des-Gly-NH2(10),Pro-ethylamide(9))-gonadotropin-releasing hormone
pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHC2H5
leuproreline
L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-L-proline ethylamide
Leuprorelin
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
leuprolide
|
|---|---|
| prefLabel |
leuprolide
|
| Definition |
An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-leucyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the acetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
|
| DBBrand |
lupron
leupromaxx
prostap 3
leupromer
eligard
leuplin
lutrate
viadur
prostap sr
enantone
memryte
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|
| ATCCode |
L02AE02
|
| modulates | |
| SMILES |
CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1
|
| InChI |
InChI=1S/C59H84N16O12/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64)/t40-,41-,42-,43+,44-,45-,46-,47-,48-/m0/s1
|
| CASRN |
53714-56-0
|
| prefixIRI |
obo2:CHEBI_6427
|
| Synonym |
pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt
C59H84N16O12
leuprorelina
leuprorelinum
5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
(D-Leu(6),des-Gly-NH2(10),Pro-ethylamide(9))-gonadotropin-releasing hormone
pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHC2H5
leuproreline
L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-L-proline ethylamide
Leuprorelin
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|
| has effect |
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|
| binds | |
| has role | |
| DBname |
leuprolide
|
| InChIKey |
InChIKey=GFIJNRVAKGFPGQ-LIJARHBVSA-N
|
| subClassOf | |
| type | |
| xref |
KEGG COMPOUND:C07612
Patent:US4005063
ChEBI:6427
DrugBank:DB00007
ChEMBL:775150
Patent:DE2446005
National Drug Code Directory:0024-0793-75
RxList:http://www.rxlist.com/cgi/generic/eligard.htm
Drugs.com:http://www.drugs.com/cdi/leuprolide.html
KEGG DRUG:D08113
Reaxys:741818
Wikipedia:http://en.wikipedia.org/wiki/Leuprolide
CASRN:53714-56-0
PharmGKB:PA450203
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|
| DBSynonym |
leuprorelin
|
| activates | |
| AHFScode |
10:00.00
|
| DBSalt |
leuprolide acetate
leuprorelin acetate
|
| has pharmacological target |
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