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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_63632
http://purl.obolibrary.org/obo/CHEBI_63632
|
|---|---|
| Preferred Name | topotecan |
| Synonyms |
(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
topotecane
Topotecan
(4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
topotecan
topotecanum
9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin
C23H23N3O5
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | topotecan
|
|---|---|
| label | topotecan
|
| DBSynonym |
topotecan lactone
topotecanum [inn-latin]
topotecan hydrochloride
topotecan hcl
topotecane [inn-french]
|
| ATCCode | L01XX17
|
| Definition | A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
|
| altId | CHEBI:9634
|
| has effect |
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| has pharmacological target | |
| induces | |
| inhibits | |
| type | |
| has role | |
| InChIKey | InChIKey=UCFGDBYHRUNTLO-QHCPKHFHSA-N
|
| AHFScode | 10:00.00
|
| Synonym | (19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
topotecane
Topotecan
(4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
topotecan
topotecanum
9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin
C23H23N3O5
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|
| xref |
PubChem Compound:60700
Drugs.com:http://www.drugs.com/cdi/topotecan.html
CiteXplore:22028494
CiteXplore:21352915
National Drug Code Directory:0007-4201-01
PharmGKB:PA451729
Patent:EP321122
RxList:http://www.rxlist.com/cgi/generic2/topotec.htm
CiteXplore:22190039
CiteXplore:21255983
ChemSpider:54705
CiteXplore:22075006
Wikipedia:Topotecan
PDB:TTC
Wikipedia:http://en.wikipedia.org/wiki/Topotecan
CiteXplore:20574789
CiteXplore:22136714
KEGG COMPOUND:C11158
PubChem Substance:46505204
CiteXplore:21910214
DrugBank:DB01030
Reaxys:4279441
Drugs Product Database (DPD):2231116
KEGG DRUG:D08618
CASRN:123948-87-8
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| CASRN | 119413-54-6
|
| prefixIRI | obo2:CHEBI_63632
|
| is transported by | |
| related with | |
| SMILES |
CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O
CC[C@@]1(O)C(=O)OCC2=C1C=C1N(CC3=CC4=C(C=CC(O)=C4CN(C)C)N=C13)C2=O
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| DBname | topotecan
|
| InChI | InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1
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| DBBrand |
hycamtin
hycamptamine
hycamptin
|
| subClassOf |
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