The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Id	http://purl.obolibrary.org/obo/CHEBI_63609 http://purl.obolibrary.org/obo/CHEBI_63609
Preferred Name	mefloquine
Synonyms	[2,8-bis(trifluoromethyl)quinolin-4-yl](piperidin-2-yl)methanol mefloquine [DL-erythro-alpha-2-Piperidyl-2,8-bis(trifluoromethyl)]-4-quinolinemethanol rac--(R)-[2,8-bis(trifluoromethyl)quinolin-4-yl][(2S)-piperidin-2-yl]methanol C17H16F6N2O mefloquinum mefloquina [(R,S)-2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol Racemic mefloquine
Type	http://www.w3.org/2002/07/owl#Class

prefLabel	mefloquine
label	mefloquine
DBSynonym	mefloquinone mefloquine hcl
ATCCode	P01BC02
Definition	A racemate composed of (+)-(11R,2'S)- and (-)-(11S,2'R)-enantiomers of mefloquine. An antimalarial agent which acts as a blood schizonticide; its mechanism of action is unknown.
altId	CHEBI:6718
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001045 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000267 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000493 http://purl.obolibrary.org/obo/OAE_0001167 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0001369 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0001026 http://purl.obolibrary.org/obo/OAE_0000287 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000494 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001135 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000842 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0001453 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0001403 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000402 See more See less
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2836 http://purl.obolibrary.org/obo/dinto_2202
inhibits	http://purl.obolibrary.org/obo/dinto_3102 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_3568 http://purl.obolibrary.org/obo/dinto_1021 See more See less
type	http://www.w3.org/2002/07/owl#Class
has role	http://purl.obolibrary.org/obo/CHEBI_38068
InChIKey	InChIKey=XEEQGYMUWCZPDN-UHFFFAOYSA-N
is metabolised by	http://purl.obolibrary.org/obo/dinto_0901
blocks	http://purl.obolibrary.org/obo/dinto_3607 http://purl.obolibrary.org/obo/dinto_2836 http://purl.obolibrary.org/obo/dinto_2202
AHFScode	08:30.08
Synonym	[2,8-bis(trifluoromethyl)quinolin-4-yl](piperidin-2-yl)methanol mefloquine [DL-erythro-alpha-2-Piperidyl-2,8-bis(trifluoromethyl)]-4-quinolinemethanol rac--(R)-[2,8-bis(trifluoromethyl)quinolin-4-yl][(2S)-piperidin-2-yl]methanol C17H16F6N2O mefloquinum mefloquina [(R,S)-2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol Racemic mefloquine See more See less
xref	CiteXplore:21853223 KEGG DRUG:D04895 Wikipedia:http://en.wikipedia.org/wiki/Mefloquine Reaxys:5306591 PubChem Compound:4046 CiteXplore:22223333 CiteXplore:22236373 Drugs Product Database (DPD):2244366 Wikipedia:Mefloquine CiteXplore:22233563 PharmGKB:PA450348 CASRN:53230-10-7 ChemSpider:3906 BindingDB:50022889 PubChem Substance:46505610 CiteXplore:21118921 CiteXplore:22006004 RxList:http://www.rxlist.com/cgi/generic2/mefloq.htm CiteXplore:22232280 CiteXplore:21861987 CiteXplore:22246492 National Drug Code Directory:54868-5434-0 DrugBank:DB00358 Drugs.com:http://www.drugs.com/cdi/mefloquine.html CiteXplore:22217970 KEGG COMPOUND:C07633 CiteXplore:22245668 See more See less
CASRN	53230-10-7
prefixIRI	obo2:CHEBI_63609
SMILES	OC(C1CCCCN1)C1=CC(=NC2=C1C=CC=C2C(F)(F)F)C(F)(F)F
DBname	mefloquine
InChI	InChI=1S/C17H16F6N2O/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11/h3-5,8,12,15,24,26H,1-2,6-7H2
DBBrand	lariam
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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