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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_63599
http://purl.obolibrary.org/obo/CHEBI_63599
|
|---|---|
| Preferred Name | fludarabine phosphate |
| Synonyms |
2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine
Fludara
Fludarabine 5'-monophosphate
FAMP
Fludarabine monophosphate
{[(2R,3S,4S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
C10H13FN5O7P
2-Fluoro-ARA AMP
9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate
2F-ara-AMP
9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate)
2-Fluoroadenine arabinoside 5'-monophosphate
9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | fludarabine phosphate
|
|---|---|
| label | fludarabine phosphate
|
| DBSynonym |
fludarabine monophosphate
fludarabine 5'-monophosphate
famp
fludarabine phosphate
|
| ATCCode | L01BB05
|
| Definition | A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas.
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| altId | CHEBI:31616
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| has effect |
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| has pharmacological target | |
| activates | |
| inhibits | |
| type | |
| has role | |
| InChIKey | InChIKey=GIUYCYHIANZCFB-FJFJXFQQSA-N
|
| AHFScode | 10:00.00
|
| Synonym |
2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine
Fludara
Fludarabine 5'-monophosphate
FAMP
Fludarabine monophosphate
{[(2R,3S,4S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
C10H13FN5O7P
2-Fluoro-ARA AMP
9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate
2F-ara-AMP
9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate)
2-Fluoroadenine arabinoside 5'-monophosphate
9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate
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|
| xref |
CiteXplore:19283354
CiteXplore:19567212
CiteXplore:20514405
PharmGKB:PA449655
ChEMBL:724161
CiteXplore:8651523
Drugs Product Database (DPD):2246226
CiteXplore:21296675
CASRN:75607-67-9
CiteXplore:20686506
KEGG DRUG:D01907
Drugs.com:http://www.drugs.com/cdi/fludarabine.html
CiteXplore:8528057
CiteXplore:20215092
CiteXplore:21736869
RxList:http://www.rxlist.com/cgi/generic/fludarabine.htm
Reaxys:8167686
CiteXplore:19915381
National Drug Code Directory:0024-5820-15
Patent:WO2010046917
Patent:WO2010133629
PubChem Substance:46507525
CiteXplore:8204523
Wikipedia:Fludarabine
Wikipedia:http://en.wikipedia.org/wiki/Fludarabine
ChemSpider:28532
CiteXplore:21909959
PubChem Compound:30751
CiteXplore:10720130
CiteXplore:21725721
DrugBank:DB01073
CiteXplore:19862681
CiteXplore:20467451
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| CASRN | 75607-67-9
|
| prefixIRI | obo2:CHEBI_63599
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| is transported by | |
| related with | |
| SMILES |
Nc1nc(F)nc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O
NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]3O)C2=NC(F)=N1
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| DBname | fludarabine
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| InChI | InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1
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| DBBrand |
fludura
fludara
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| subClassOf |
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