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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_63584
http://purl.obolibrary.org/obo/CHEBI_63584
|
|---|---|
| Preferred Name | cabazitaxel |
| Synonyms |
(2alpha,5beta,7beta,10beta,13alpha)-4-acetoxy-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-15-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl benzoate
cabazitaxel
C45H57NO14
cabazitaxelum
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | cabazitaxel
|
|---|---|
| label | cabazitaxel
|
| DBSynonym |
xrp6258
taxoid xrp6258
rpr-116258a
rpr116258
txd258
|
| ATCCode | L01CD04
|
| Definition | A tetracyclic diterpenoid that is 10-deacetylbaccatin III having O-methyl groups attached at positions 7 and 10 as well as an O-(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl group attached at position 13. Acts as a microtubule inhibitor, binds tubulin and promotes microtubule assembly and simultaneously inhibits disassembly.
|
| has pharmacological target | |
| inhibits | |
| type | |
| binds | |
| has role | |
| InChIKey | InChIKey=BMQGVNUXMIRLCK-OAGWZNDDSA-N
|
| is metabolised by | |
| AHFScode | 10:00
|
| Synonym | (2alpha,5beta,7beta,10beta,13alpha)-4-acetoxy-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-15-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl benzoate
cabazitaxel
C45H57NO14
cabazitaxelum
|
| xref |
CiteXplore:21448449
CiteXplore:21734586
CiteXplore:22048000
CiteXplore:22111007
KEGG DRUG:D09755
CiteXplore:21695098
CiteXplore:22229405
CiteXplore:21748753
ChEBI:63584
Wikipedia:http://en.wikipedia.org/wiki/Cabazitaxel
Wikipedia:Cabazitaxel
CiteXplore:21174534
PubChem Substance:99443289
CiteXplore:21463139
ChEMBL:775699
CiteXplore:21339064
Reaxys:14351224
PharmGKB:PA165958401
ChemSpider:8029779
DrugBank:DB06772
CASRN:183133-96-2
RxList:http://www.rxlist.com/jevtana-drug.htm
CiteXplore:21461278
CiteXplore:21455038
PubChem Compound:9854073
CiteXplore:22079047
Drugs.com:http://www.drugs.com/pro/jevtana.html
CiteXplore:21406025
National Drug Code Directory:0024-5824-11
CiteXplore:21770474
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| CASRN | 183133-96-2
|
| prefixIRI | obo2:CHEBI_63584
|
| is transported by | |
| SMILES | [H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C(C)=C([C@@H](OC)C(=O)[C@]1(C)[C@H](C[C@H]1OC[C@@]21OC(C)=O)OC)C3(C)C
[H][C@@](O)([C@@H](NC(=O)OC(C)(C)C)C1=CC=CC=C1)C(=O)O[C@@]1([H])C[C@@]2(O)[C@@]([H])(OC(=O)C3=CC=CC=C3)[C@]3([H])[C@@]4(CO[C@]4([H])C[C@]([H])(OC)[C@@]3(C)C(=O)[C@]([H])(OC)C(=C1C)C2(C)C)OC(C)=O
|
| may interact with |
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| DBname | cabazitaxel
|
| InChI | InChI=1S/C45H57NO14/c1-24-28(57-39(51)33(48)32(26-17-13-11-14-18-26)46-40(52)60-41(3,4)5)22-45(53)37(58-38(50)27-19-15-12-16-20-27)35-43(8,36(49)34(55-10)31(24)42(45,6)7)29(54-9)21-30-44(35,23-56-30)59-25(2)47/h11-20,28-30,32-35,37,48,53H,21-23H2,1-10H3,(H,46,52)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1
|
| DBBrand | jevtana
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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