The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Id	http://purl.obolibrary.org/obo/CHEBI_567361 http://purl.obolibrary.org/obo/CHEBI_567361
Preferred Name	cladribine
Synonyms	2-chloro-2'-deoxy-beta-adenosine (2R,3S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol 2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine CldAdo 2-chlorodeoxyadenosine 2ClAdo cladribinum (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol C10H12ClN5O3 2-chloro-2'-deoxyadenosine cladribina 2-chloro-deoxyadenosine cladribine 2-CdA Cladribine See more See less
Type	http://www.w3.org/2002/07/owl#Class

prefLabel	cladribine
label	cladribine
DBSynonym	2-chloro-2'-deoxy-beta-adenosine 2-cda 2-chlorodeoxyadenosine 2-chloro-2'-deoxyadenosine chlorodeoxyadenosine
ATCCode	L01BB04
Definition	2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia.
altId	CHEBI:31407 CHEBI:568373
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000424 http://purl.obolibrary.org/obo/OAE_0001154 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000267 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0001485 http://purl.obolibrary.org/obo/OAE_0000169 http://purl.obolibrary.org/obo/OAE_0000103 http://purl.obolibrary.org/obo/OAE_0001053 http://purl.obolibrary.org/obo/OAE_0000287 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0000943 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0001198 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000194 http://purl.obolibrary.org/obo/OAE_0001205 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000185 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001291 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000618 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402 See more See less
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2873 http://purl.obolibrary.org/obo/dinto_1599 http://purl.obolibrary.org/obo/dinto_2102 http://purl.obolibrary.org/obo/dinto_3867 http://purl.obolibrary.org/obo/dinto_1969 http://purl.obolibrary.org/obo/dinto_1954 http://purl.obolibrary.org/obo/dinto_1949 http://purl.obolibrary.org/obo/dinto_1940 http://purl.obolibrary.org/obo/dinto_1943 http://purl.obolibrary.org/obo/dinto_2381 See more See less
induces	http://purl.obolibrary.org/obo/dinto_2102
inhibits	http://purl.obolibrary.org/obo/dinto_1599 http://purl.obolibrary.org/obo/dinto_3867 http://purl.obolibrary.org/obo/dinto_1969 http://purl.obolibrary.org/obo/dinto_1954 http://purl.obolibrary.org/obo/dinto_1949 http://purl.obolibrary.org/obo/dinto_1940 http://purl.obolibrary.org/obo/dinto_1943 http://purl.obolibrary.org/obo/dinto_2381 See more See less
type	http://www.w3.org/2002/07/owl#Class
has role	http://purl.obolibrary.org/obo/CHEBI_35705 http://purl.obolibrary.org/obo/CHEBI_35610
InChIKey	InChIKey=PTOAARAWEBMLNO-KVQBGUIXSA-N
is metabolised by	http://purl.obolibrary.org/obo/dinto_2044
AHFScode	10:00.00
Synonym	2-chloro-2'-deoxy-beta-adenosine (2R,3S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol 2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine CldAdo 2-chlorodeoxyadenosine 2ClAdo cladribinum (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol C10H12ClN5O3 2-chloro-2'-deoxyadenosine cladribina 2-chloro-deoxyadenosine cladribine 2-CdA Cladribine See more See less
xref	Drugs Product Database (DPD):2022117 ChemSpider:19105 DrugBank:DB00242 ChEBI:567361 ChEMBL:18570408 Beilstein:624220 Wikipedia:http://en.wikipedia.org/wiki/Cladribine ChEMBL:17526755 PubChem Compound:20279 Patent:EP173059 National Drug Code Directory:59676-201-01 PubChem Substance:46504588 RxList:http://www.rxlist.com/cgi/generic3/cladribine.htm PharmGKB:PA449027 Wikipedia:Cladribine CASRN:4291-63-8 KEGG DRUG:D01370 Drugs.com:http://www.drugs.com/cdi/cladribine.html Patent:US4760137 See more See less
CASRN	4291-63-8
prefixIRI	obo2:CHEBI_567361
is transported by	http://purl.obolibrary.org/obo/dinto_1979 http://purl.obolibrary.org/obo/dinto_1970 http://purl.obolibrary.org/obo/dinto_0883
related with	http://purl.obolibrary.org/obo/dinto_2873 http://purl.obolibrary.org/obo/dinto_1885
SMILES	Nc1nc(Cl)nc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1 NC1=C2N=CN([C@H]3C[C@H](O)[C@@H](CO)O3)C2=NC(Cl)=N1
may interact with	http://purl.obolibrary.org/obo/dinto_DB00108 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/CHEBI_47657 http://purl.obolibrary.org/obo/dinto_DB00072 http://purl.obolibrary.org/obo/dinto_DB00337 http://purl.obolibrary.org/obo/CHEBI_6402 See more See less
DBname	cladribine
InChI	InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
DBBrand	mylinax leustatin
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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