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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_52717
http://purl.obolibrary.org/obo/CHEBI_52717
|
|---|---|
| Preferred Name | bortezomib |
| Synonyms |
N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N(alpha)-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide
C19H25BN4O4
N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
[(1R)-3-methyl-1-[(2S)-3-phenyl-2-(pyrazin-2-ylformamido)propanamido]butyl]boronic acid
Velcade
[(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid
PS 341
bortezomib
PS-341
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | bortezomib
|
|---|---|
| label | bortezomib
|
| ATCCode | L01XX32
|
| Definition | L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
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| altId | CHEBI:41143
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| has effect |
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| has pharmacological target | |
| inhibits |
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| type | |
| has role | |
| InChIKey | InChIKey=GXJABQQUPOEUTA-RDJZCZTQSA-N
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| is metabolised by | |
| blocks | |
| AHFScode | 10:00.00
|
| Synonym |
N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N(alpha)-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide
C19H25BN4O4
N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
[(1R)-3-methyl-1-[(2S)-3-phenyl-2-(pyrazin-2-ylformamido)propanamido]butyl]boronic acid
Velcade
[(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid
PS 341
bortezomib
PS-341
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|
| xref |
PDBeChem:BO2
ChEMBL:287372
CiteXplore:21504411
CiteXplore:21865767
RxList:http://www.rxlist.com/cgi/generic3/velcade.htm
DrugBank:DB00188
ChEBI:52717
Reaxys:8723817
CiteXplore:18484921
National Drug Code Directory:63020-049-01
KEGG DRUG:D03150
Wikipedia:http://en.wikipedia.org/wiki/Bortezomib
PharmGKB:PA10252
Wikipedia:Bortezomib
Drugs Product Database (DPD):2262452
CASRN:179324-69-7
CiteXplore:18980173
Drugs.com:http://www.drugs.com/cdi/bortezomib.html
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| CASRN | 179324-69-7
|
| prefixIRI | obo2:CHEBI_52717
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| SMILES |
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C1=CN=CC=N1)B(O)O
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| may interact with | |
| DBname | bortezomib
|
| InChI | InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
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| DBBrand | velcade
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| subClassOf |
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| No notes to display |