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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_5000
http://purl.obolibrary.org/obo/CHEBI_5000
|
|---|---|
| Preferred Name | fenfluramine |
| Synonyms |
2-ethylamino-1-(3-trifluoromethylphenyl)propane
fenfluraminum
(+-)-fenfluramine
N-ethyl-1-(3-(trifluoromethyl)phenyl)propan-2-amine
1-(m-trifluoromethyl-phenyl)-2-ethylaminopropane
3-(trifluoromethyl)-N-ethyl-alpha-methylphenethylamine
ethyl({1-[3-(trifluoromethyl)phenyl]propan-2-yl})amine
N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
Ethyl-[1-methyl-2-(3-trifluoromethyl-phenyl)-ethyl]-amine
fenfluramine
Fenfluramine
C12H16F3N
N-ethyl-alpha-methyl-3-trifluoromethylphenethylamine
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | fenfluramine
|
|---|---|
| label | fenfluramine
|
| DBSynonym |
fenfluraminum [inn-latin]
dea no. 1670
fenfluramine hydrochloride
fenfluramina [dcit]
|
| ATCCode |
A08AA04
A08AA02
|
| Definition | 1-Phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
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| altId | CHEBI:239434
|
| has pharmacological target | |
| activates | |
| inhibits | |
| type | |
| has role | |
| InChIKey | InChIKey=DBGIVFWFUFKIQN-UHFFFAOYSA-N
|
| Synonym |
2-ethylamino-1-(3-trifluoromethylphenyl)propane
fenfluraminum
(+-)-fenfluramine
N-ethyl-1-(3-(trifluoromethyl)phenyl)propan-2-amine
1-(m-trifluoromethyl-phenyl)-2-ethylaminopropane
3-(trifluoromethyl)-N-ethyl-alpha-methylphenethylamine
ethyl({1-[3-(trifluoromethyl)phenyl]propan-2-yl})amine
N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
Ethyl-[1-methyl-2-(3-trifluoromethyl-phenyl)-ethyl]-amine
fenfluramine
Fenfluramine
C12H16F3N
N-ethyl-alpha-methyl-3-trifluoromethylphenethylamine
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|
| xref |
KEGG COMPOUND:C06996
DrugBank:DB00574
Wikipedia:http://en.wikipedia.org/wiki/Fenfluramine
PubChem Compound:3337
NIST Chemistry WebBook:458-24-2
RxList:http://www.rxlist.com/cgi/generic/fenflur.htm
Patent:US3198833
PharmGKB:PA449592
Drugs Product Database (DPD):1914057
Beilstein:2109374
CASRN:458-24-2
ChemSpider:3220
KEGG DRUG:D07945
ChEBI:5000
PubChem Substance:46506096
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| CASRN | 458-24-2
|
| prefixIRI | obo2:CHEBI_5000
|
| SMILES |
CCNC(C)CC1=CC(=CC=C1)C(F)(F)F
CCNC(C)Cc1cccc(c1)C(F)(F)F
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| may interact with |
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| DBname | fenfluramine
|
| InChI | InChI=1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3
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| DBBrand |
pondimin
rotondin
ponderex
ponderax pa
pesos
obedrex
acino
adipomin
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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