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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_4822
http://purl.obolibrary.org/obo/CHEBI_4822
|
|---|---|
| Preferred Name | ergometrine |
| Synonyms |
[8beta(S)]-9,10-didehydro-N-(2-hydroxy-1-methylethyl)-6-methylergoline-8-carboxamide
Ergonovine
N-(2-Hydroxy-1-methylethyl)-D(+)-lysergamide
(6aR,9R)-7-Methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid ((S)-2-hydroxy-1-methyl-ethyl)-amide
C19H23N3O2
9,10-didehydro-N-(alpha-(hydroxymethyl)ethyl)-6-methylergoline-8-beta-carboxamide
ergometrina
N-(alpha-(hydroxymethyl)ethyl)-D-lysergamide
ergometrinum
N-[(2S)-1-hydroxypropan-2-yl]-6-methyl-9,10-didehydroergoline-8beta-carboxamide
ergometrine
9,10-didehydro-N-(2-hydroxy-1-methylethyl)-6-methylergoline-8beta(S)-carboxamide
D-lysergic acid-L-propanolamide
Ergometrine
D-lysergic acid 1-hydroxymethylethylamide
(4R,7R)-N-[(2S)-1-hydroxypropan-2-yl]-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | ergometrine
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|---|---|
| label | ergometrine
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| DBSynonym |
ergotrate maleate
ergobasine
ergometrine
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| ATCCode | G02AB03
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| Definition | Lysergamide in which one of the hydrogens attached to the amide nitrogen is substituted by a 1-hydroxypropan-2-yl group (S-configuration). An ergot alkaloid that has a particularly powerful action on the uterus, its maleate (and formerly tartrate) salt is used in the active management of the third stage of labour, and to prevent or treat postpartum of postabortal haemorrhage caused by uterine atony: by maintaining uterine contraction and tone, blood vessels in the uterine wall are compressed and blood flow reduced. The maleate salt has also been used in the diagnosis of oesophageal spasm, and in a provocation test for the diagnosis of Prinzmetal's angina.
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| altId | CHEBI:296351
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| has pharmacological target | |
| activates | |
| inhibits | |
| type | |
| has role | |
| InChIKey | InChIKey=WVVSZNPYNCNODU-XTQGRXLLSA-N
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| is metabolised by | |
| AHFScode | 76:00.00
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| Synonym | [8beta(S)]-9,10-didehydro-N-(2-hydroxy-1-methylethyl)-6-methylergoline-8-carboxamide
Ergonovine
N-(2-Hydroxy-1-methylethyl)-D(+)-lysergamide
(6aR,9R)-7-Methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid ((S)-2-hydroxy-1-methyl-ethyl)-amide
C19H23N3O2
9,10-didehydro-N-(alpha-(hydroxymethyl)ethyl)-6-methylergoline-8-beta-carboxamide
ergometrina
N-(alpha-(hydroxymethyl)ethyl)-D-lysergamide
ergometrinum
N-[(2S)-1-hydroxypropan-2-yl]-6-methyl-9,10-didehydroergoline-8beta-carboxamide
ergometrine
9,10-didehydro-N-(2-hydroxy-1-methylethyl)-6-methylergoline-8beta(S)-carboxamide
D-lysergic acid-L-propanolamide
Ergometrine
D-lysergic acid 1-hydroxymethylethylamide
(4R,7R)-N-[(2S)-1-hydroxypropan-2-yl]-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide
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| xref |
ChEBI:4822
CASRN:60-79-7
Patent:US2809920
KEGG COMPOUND:C07543
PubChem Substance:46506922
Beilstein:94902
Drugs.com:http://www.drugs.com/cdi/ergonovine.html
PubChem Compound:443884
PharmGKB:PA449487
DrugBank:DB01253
ChemSpider:391970
Patent:US2736728
Wikipedia:http://en.wikipedia.org/wiki/Ergonovine
Drugs Product Database (DPD):497312
ChEMBL:7190615
Patent:US3141887
KEGG DRUG:D07905
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| CASRN | 60-79-7
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| prefixIRI | obo2:CHEBI_4822
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| SMILES |
[H][C@@]12CC3=CNC4=CC=CC(=C34)C1=C[C@H](CN2C)C(=O)N[C@@H](C)CO
[H][C@@]12Cc3c[nH]c4cccc(C1=C[C@H](CN2C)C(=O)N[C@@H](C)CO)c34
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| may interact with |
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| DBname | ergonovine
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| InChI | InChI=1S/C19H23N3O2/c1-11(10-23)21-19(24)13-6-15-14-4-3-5-16-18(14)12(8-20-16)7-17(15)22(2)9-13/h3-6,8,11,13,17,20,23H,7,9-10H2,1-2H3,(H,21,24)/t11-,13+,17+/m0/s1
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| DBBrand | ergotrate
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| subClassOf |
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