Link to this page
The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_4707
http://purl.obolibrary.org/obo/CHEBI_4707
|
|---|---|
| Preferred Name | doxacurium chloride |
| Synonyms |
doxacurii chloridum
cloruro de doxacurio
chlorure de doxacurium
C56H78N2O16
doxacurium chloride
6,7,8-trimethoxy-2-methyl-2-(3-{[4-oxo-4-(3-{6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium-2-yl}propoxy)butanoyl]oxy}propyl)-1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium
C56H78Cl2N2O16
(1R,2S;1S,2R)-1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride, succinate (2:1), mixture with (+-)-(1R*,2S*;1R*,2S*)-1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride, succinate (2:1)
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | doxacurium chloride
|
|---|---|
| label | doxacurium chloride
|
| ATCCode | M03AC07
|
| Definition | The dichloride salt of doxacurium. It is a mixture of the (1R,2S,1'S,2'R), (1R,2S,1'R,2'S) and (1S,2R,1'S,2'R) stereoisomers (a meso isomer and two enantiomers, respectively) of 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxypropane-3,1-diyl)]bis[6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium] dichloride, all of which are in a trans configuration at the 1 and 2 positions of the tetrahydroisoquinolinium rings. A competitive neuromuscular blocker, it is used to provide muscle relaxation in general anaesthesia and to facilitate mechanical ventilation in patients in intensive care.
|
| has pharmacological target | |
| type | |
| has role | |
| InChIKey | InChIKey=GBLRQXKSCRCLBZ-UHFFFAOYSA-N
|
| is metabolised by | |
| blocks | |
| AHFScode | 12:20.00
|
| Synonym | doxacurii chloridum
cloruro de doxacurio
chlorure de doxacurium
C56H78N2O16
doxacurium chloride
6,7,8-trimethoxy-2-methyl-2-(3-{[4-oxo-4-(3-{6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium-2-yl}propoxy)butanoyl]oxy}propyl)-1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium
C56H78Cl2N2O16
(1R,2S;1S,2R)-1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride, succinate (2:1), mixture with (+-)-(1R*,2S*;1R*,2S*)-1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride, succinate (2:1)
See more
See less
|
| xref |
DrugBank:DB01334
CASRN:106819-53-8
RxList:http://www.rxlist.com/cgi/generic3/doxacur.htm
Drugs Product Database (DPD):1924656
DrugBank:DB01135
PubChem Compound:60169
ChEBI:4707
Wikipedia:http://en.wikipedia.org/wiki/Doxacurium_chloride
PubChem Substance:46506733
PharmGKB:PA164744927
Beilstein:9184298
ChemSpider:54249
KEGG DRUG:D00760
Patent:US4701460
Beilstein:9689361
National Drug Code Directory:0074-4437-05
See more
See less
|
| CASRN | 106819-53-8
|
| prefixIRI | obo2:CHEBI_4707
|
| SMILES | COC1=CC(CC2C3=C(CC[N+]2(C)CCCOC(=O)CCC(=O)OCCC[N+]2(C)CCC4=C(C2CC2=CC(OC)=C(OC)C(OC)=C2)C(OC)=C(OC)C(OC)=C4)C=C(OC)C(OC)=C3OC)=CC(OC)=C1OC
|
| may interact with |
See more
See less
|
| DBname | doxacurium chloride
|
| InChI | InChI=1S/C56H78N2O16/c1-57(23-19-37-33-45(65-7)53(69-11)55(71-13)49(37)39(57)27-35-29-41(61-3)51(67-9)42(30-35)62-4)21-15-25-73-47(59)17-18-48(60)74-26-16-22-58(2)24-20-38-34-46(66-8)54(70-12)56(72-14)50(38)40(58)28-36-31-43(63-5)52(68-10)44(32-36)64-6/h29-34,39-40H,15-28H2,1-14H3/q+2
|
| DBBrand | nuromax
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |