The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Id	http://purl.obolibrary.org/obo/CHEBI_46345 http://purl.obolibrary.org/obo/CHEBI_46345
Preferred Name	5-fluorouracil
Synonyms	5-FU Fluorouracil C4H3FN2O2 fluorouracil fluorouracilo fluorouracilum 5-Fluoracil 5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione 5-Fluorouracil 5-Fluoropyrimidine-2,4-dione 5-fluorouracil 5-fluoropyrimidine-2,4(1H,3H)-dione See more See less
Type	http://www.w3.org/2002/07/owl#Class

prefLabel	5-fluorouracil
label	5-fluorouracil
DBSynonym	fluoro uracil 5-fluracil fu fluouracil 5-fu 5-fluorouracil See more See less
ATCCode	L01BC02
Definition	A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
altId	CHEBI:2054 CHEBI:46343
has effect	http://purl.obolibrary.org/obo/OAE_0000259 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0000303 http://purl.obolibrary.org/obo/OAE_0000236 http://purl.obolibrary.org/obo/OAE_0000557 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000198 http://purl.obolibrary.org/obo/OAE_0000267 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0001360 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000249 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0001064 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0001397 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0000687 http://purl.obolibrary.org/obo/OAE_0001234 http://purl.obolibrary.org/obo/OAE_0001105 http://purl.obolibrary.org/obo/OAE_0000943 http://purl.obolibrary.org/obo/OAE_0000312 http://purl.obolibrary.org/obo/OAE_0001200 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000494 http://purl.obolibrary.org/obo/OAE_0000510 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0001382 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000341 http://purl.obolibrary.org/obo/OAE_0000799 http://purl.obolibrary.org/obo/OAE_0000894 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0000329 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000898 http://purl.obolibrary.org/obo/OAE_0000800 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001345 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000881 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000716 See more See less
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2873 http://purl.obolibrary.org/obo/dinto_0144 http://purl.obolibrary.org/obo/dinto_1622
inhibits	http://purl.obolibrary.org/obo/dinto_2058
type	http://www.w3.org/2002/07/owl#Class
has role	http://purl.obolibrary.org/obo/CHEBI_35705 http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_35221
InChIKey	InChIKey=GHASVSINZRGABV-UHFFFAOYSA-N
is metabolised by	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_3619 http://purl.obolibrary.org/obo/dinto_1821 http://purl.obolibrary.org/obo/dinto_1622 http://purl.obolibrary.org/obo/dinto_2414 http://purl.obolibrary.org/obo/dinto_2419 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_0602 http://purl.obolibrary.org/obo/dinto_3587 http://purl.obolibrary.org/obo/dinto_2755 http://purl.obolibrary.org/obo/dinto_1221 See more See less
AHFScode	84:92.00 10:00.00
Synonym	5-FU Fluorouracil C4H3FN2O2 fluorouracil fluorouracilo fluorouracilum 5-Fluoracil 5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione 5-Fluorouracil 5-Fluoropyrimidine-2,4-dione 5-fluorouracil 5-fluoropyrimidine-2,4(1H,3H)-dione See more See less
xref	Drugs Product Database (DPD):2182742 ChEBI:46345 KEGG COMPOUND:C07649 National Drug Code Directory:0703-3015-13 RxList:http://www.rxlist.com/cgi/generic3/carac.htm PDBeChem:URF DrugBank:DB00544 Drugs.com:http://www.drugs.com/cdi/fluorouracil.html Reaxys:127172 ChEMBL:468538 Wikipedia:Fluorouracil PubChem Compound:3385 PharmGKB:PA128406956 KEGG DRUG:D00584 PubChem Substance:46508557 Beilstein:127172 ChemSpider:3268 CASRN:51-21-8 Wikipedia:http://en.wikipedia.org/wiki/Fluorouracil PDB:URF See more See less
CASRN	51-21-8
prefixIRI	obo2:CHEBI_46345
is transported by	http://purl.obolibrary.org/obo/dinto_0588 http://purl.obolibrary.org/obo/dinto_0718 http://purl.obolibrary.org/obo/dinto_1977 http://purl.obolibrary.org/obo/dinto_0883 http://purl.obolibrary.org/obo/dinto_1992 http://purl.obolibrary.org/obo/dinto_0300 See more See less
related with	http://purl.obolibrary.org/obo/dinto_2873 http://purl.obolibrary.org/obo/dinto_0144 http://purl.obolibrary.org/obo/dinto_1622 http://purl.obolibrary.org/obo/dinto_0217
SMILES	Fc1c[nH]c(=O)[nH]c1=O FC1=CNC(=O)NC1=O
may interact with	http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/CHEBI_10100 http://purl.obolibrary.org/obo/CHEBI_41774 http://purl.obolibrary.org/obo/CHEBI_4888 http://purl.obolibrary.org/obo/dinto_DB00532 http://purl.obolibrary.org/obo/dinto_DB06287 http://purl.obolibrary.org/obo/dinto_DB00214 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/CHEBI_6909 http://purl.obolibrary.org/obo/dinto_DB00440 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/dinto_DB00072 http://purl.obolibrary.org/obo/dinto_DB01320 http://purl.obolibrary.org/obo/CHEBI_27999 See more See less
DBname	fluorouracil
InChI	InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
DBBrand	fluril fluoroplex fluracilum efudix efurix urf effluderm fluri ftoruracil carac queroplex kecimeton efudex adrucil fluoroblastin timazin phtoruracil arumel carzonal phthoruracil ulup See more See less
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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