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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_4450
http://purl.obolibrary.org/obo/CHEBI_4450
|
|---|---|
| Preferred Name | desmopressin |
| Synonyms |
desmopressine
1-(3-mercaptopropionic acid)-8-D-arginine-vasopressin
desmopresina
desmopressinum
(2S)-2-{[(2S)-1-{[(4R,7S,10S,13S,16S)-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}pyrrolidin-2-yl]formamido}-5-carbamimidamido-N-(carbamoylmethyl)pentanamide
1-deamino-8-D-arginine vasopressin
desmopressin
1-desamino-8-D-arginine vasopressin
C46H64N14O12S2
DDAVP
1-{[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-D-arginylglycinamide
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | desmopressin
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|---|---|
| label | desmopressin
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| DBSynonym |
1-desamino-8-d-arginine vasopressin
desmopresina [inn-spanish]
desmopressine [inn-french]
desmopressinum [inn-latin]
|
| ATCCode | H01BA02
|
| Definition | A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. An antidiuretic, it increases urine concentration and decreases urine production, and is used (usually as the trihydrate of the acetic acid salt) to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial diabetes insipidus and in tests of renal function.
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| has effect |
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| DBSalt | desmopressin acetate
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| has pharmacological target | |
| induces | |
| activates | |
| type | |
| has role | |
| InChIKey |
InChIKey=NFLWUMRGJYTJIN-PNIOQBSNSA-N
InChIKey=NFLWUMRGJYTJIN-NXBWRCJVSA-N
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| AHFScode | 68:28.00
|
| Synonym | desmopressine
1-(3-mercaptopropionic acid)-8-D-arginine-vasopressin
desmopresina
desmopressinum
(2S)-2-{[(2S)-1-{[(4R,7S,10S,13S,16S)-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}pyrrolidin-2-yl]formamido}-5-carbamimidamido-N-(carbamoylmethyl)pentanamide
1-deamino-8-D-arginine vasopressin
desmopressin
1-desamino-8-D-arginine vasopressin
C46H64N14O12S2
DDAVP
1-{[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-D-arginylglycinamide
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| xref |
CASRN:16679-58-6
KEGG COMPOUND:C06944
Wikipedia:http://en.wikipedia.org/wiki/Desmopressin
KEGG DRUG:D00291
National Drug Code Directory:55566-5020-1
PharmGKB:PA449237
RxList:http://www.rxlist.com/cgi/generic3/desmoprt.htm
Beilstein:4651966
ChEMBL:466868
Drugs.com:http://www.drugs.com/cdi/desmopressin.html
DrugBank:DB00035
Drugs Product Database (DPD):2257718
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| CASRN | 16679-58-6
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| prefixIRI | obo2:CHEBI_4450
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| related with | |
| SMILES | NC(=N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
NC(=O)CC[C@@H]1NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O
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| DBname | desmopressin
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| InChI | InChI=1S/C46H64N14O12S2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52)/t28-,29-,30-,31-,32-,33-,34-/m0/s1
InChI=1S/C46H64N14O12S2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52)/t28-,29+,30+,31+,32+,33+,34+/m1/s1
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| DBBrand |
stimate
adiuretin
ddavp
minirin
concentraid
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| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
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