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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_4031
http://purl.obolibrary.org/obo/CHEBI_4031
|
|---|---|
| Preferred Name | cyclosporin A |
| Synonyms |
30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
Cyclosporin A
1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine]
ciclosporin
Cyclosporine
Gengraf
Neoral
ciclosporina
Antibiotic S 7481F1
Sandimmune
30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
ciclosporinum
Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl)
Ciclosporin
30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
C62H111N11O12
ciclosporine
(R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | cyclosporin A
|
|---|---|
| label | cyclosporin A
|
| DBSynonym |
cyclosporin a
csa
ciclosporin
cya
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| ATCCode |
S01XA18
L04AD01
|
| Definition | A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
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| altId | CHEBI:63586
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| has effect |
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| has pharmacological target | |
| induces | |
| inhibits |
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| type | |
| binds | |
| has role |
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| InChIKey |
InChIKey=PMATZTZNYRCHOR-IMVLJIQENA-N
InChIKey=PMATZTZNYRCHOR-VJRYSDSKSA-N
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| is metabolised by | |
| AHFScode | 92:00.00
|
| Synonym | 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
Cyclosporin A
1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine]
ciclosporin
Cyclosporine
Gengraf
Neoral
ciclosporina
Antibiotic S 7481F1
Sandimmune
30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
ciclosporinum
Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl)
Ciclosporin
30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
C62H111N11O12
ciclosporine
(R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl)
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| xref |
CiteXplore:14621732
CiteXplore:19282398
CiteXplore:11058832
CiteXplore:15613074
CiteXplore:18171316
CiteXplore:11529914
CiteXplore:17603747
CiteXplore:18790203
CiteXplore:17117422
CiteXplore:17192032
Wikipedia:Ciclosporin
CiteXplore:12761440
CiteXplore:18259730
CiteXplore:12950728
CiteXplore:14743390
KEGG DRUG:D00184
CiteXplore:15383526
CiteXplore:15626898
CiteXplore:11370709
CiteXplore:18076075
Beilstein:3647785
CiteXplore:19589783
CiteXplore:11564166
Reaxys:3647785
CiteXplore:18597363
CiteXplore:11278005
Drugs Product Database (DPD):593257
CiteXplore:11080188
CiteXplore:17083576
CiteXplore:17220244
CiteXplore:11238591
CiteXplore:18931077
Drugs.com:http://www.drugs.com/cdi/cyclosporine-drops.html
PharmGKB:PA449167
CiteXplore:16724420
CiteXplore:11676831
CiteXplore:18359899
CiteXplore:12021257
CiteXplore:16404634
CiteXplore:17265451
CiteXplore:14682659
CiteXplore:11406057
CiteXplore:11079273
CiteXplore:12050171
CiteXplore:12603598
CiteXplore:11870366
CiteXplore:11069928
CiteXplore:11493684
KEGG COMPOUND:C05086
CiteXplore:16372476
CiteXplore:11426833
CiteXplore:14521916
CiteXplore:15030555
CiteXplore:14672695
CiteXplore:15306697
CiteXplore:18975184
Wikipedia:http://en.wikipedia.org/wiki/Cyclosporine
CiteXplore:15541012
RxList:http://www.rxlist.com/cgi/generic/cyclosporine.htm
CiteXplore:18818682
CiteXplore:17032751
CiteXplore:18299432
CiteXplore:16898534
CiteXplore:11315347
CiteXplore:18217899
CiteXplore:15711594
CiteXplore:18191430
ChEBI:4031
CASRN:59865-13-3
CiteXplore:16801218
CiteXplore:15175101
CiteXplore:15657176
CiteXplore:14638917
CiteXplore:18583716
National Drug Code Directory:0078-0240-15
CiteXplore:11557554
CiteXplore:17229932
CiteXplore:11256490
Patent:US4117118
CiteXplore:15811524
DrugBank:DB00091
CiteXplore:15210365
CiteXplore:12929192
CiteXplore:17446460
CiteXplore:11442023
CiteXplore:1566062
CiteXplore:11481617
CiteXplore:15962181
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| CASRN | 59865-13-3
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| prefixIRI | obo2:CHEBI_4031
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| is transported by | |
| related with | |
| SMILES | CC[C@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\\C=C\\C)N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
CCC1NC(=O)C(C(O)C(C)C\C=C\C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
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| may interact with |
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| DBname | cyclosporine
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| InChI | InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42+,43-,44+,45-,46+,47+,49+,50-,51+,52-/m1/s1
InChI=1/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+
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| DBBrand |
sandimmune
neoral
gengraf
restasis
sangcya
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| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |