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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_3395
http://purl.obolibrary.org/obo/CHEBI_3395
|
|---|---|
| Preferred Name | carbidopa |
| Synonyms |
C10H16N2O5
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid--water (1/1)
(S)-carbidopa hydrate
L-alpha-(3,4-dihydroxybenzyl)-alpha-hydrazinopropionic acid monohydrate
(alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid monohydrate
(-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate
carbidopa monohydrate
(S)-(-)-carbidopa hydrate
carbidopum monohydricum
carbidopa hydrate
carbidopa
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate
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|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | carbidopa
|
|---|---|
| label | carbidopa
|
| DBSynonym |
alpha-methyldopahydrazine
n-aminomethyldopa
carbidopa monohydrate
carbidopum [inn-latin]
carbidopa anhydrous
c-dopa
mk-486
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|
| Definition | The hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.
|
| altId | CHEBI:212626
|
| has pharmacological target | |
| inhibits | |
| type | |
| has role | |
| InChIKey | InChIKey=QTAOMKOIBXZKND-PPHPATTJSA-N
|
| Synonym |
C10H16N2O5
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid--water (1/1)
(S)-carbidopa hydrate
L-alpha-(3,4-dihydroxybenzyl)-alpha-hydrazinopropionic acid monohydrate
(alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid monohydrate
(-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate
carbidopa monohydrate
(S)-(-)-carbidopa hydrate
carbidopum monohydricum
carbidopa hydrate
carbidopa
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate
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|
| xref |
Patent:GB940596
Drugs.com:http://www.drugs.com/cdi/carbidopa.html
Wikipedia:http://en.wikipedia.org/wiki/Carbidopa
Patent:DE2062285
PharmGKB:PA448794
DrugBank:DB00190
ChEBI:3395
RxList:http://www.rxlist.com/cgi/generic/sinemet.htm
CASRN:38821-49-7
National Drug Code Directory:0056-0511-68
ChEMBL:774699
Patent:DE2062332
Patent:US3462536
ChEMBL:10841799
KEGG DRUG:D00558
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|
| CASRN | 28860-95-9
|
| prefixIRI | obo2:CHEBI_3395
|
| SMILES |
O.C[C@@](Cc1ccc(O)c(O)c1)(NN)C(O)=O
O.C[C@@](CC1=CC(O)=C(O)C=C1)(NN)C(O)=O
|
| DBname | carbidopa
|
| InChI | InChI=1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/m0./s1
|
| DBBrand |
atamet
lodosyn
hmd
lodosin
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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