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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_3286
http://purl.obolibrary.org/obo/CHEBI_3286
|
|---|---|
| Preferred Name | cabergoline |
| Synonyms |
Cabergoline
1-[3-(dimethylamino)propyl]-3-ethyl-1-{[(2R,4R,7R)-6-(prop-2-en-1-yl)-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraen-4-yl]carbonyl}urea
1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
(8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide
1-[(6-allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea
(8beta)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-6-(prop-2-en-1-yl)ergoline-8-carboxamide
cabergolinum
cabergolina
(8R)-6-allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide
cabergoline
C26H37N5O2
1-ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | cabergoline
|
|---|---|
| label | cabergoline
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| DBSynonym |
cabergolinum [latin]
cabergolina [spanish]
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| ATCCode |
N04BC06
G02CB03
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| Definition | An N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substituted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson's disease and of disorders associated with hyperprolactinaemia.
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| has effect |
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| has pharmacological target | |
| activates |
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| inhibits | |
| type | |
| has role | |
| InChIKey | InChIKey=KORNTPPJEAJQIU-KJXAQDMKSA-N
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| is metabolised by | |
| blocks | |
| AHFScode | 28:36.20.04
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| Synonym | Cabergoline
1-[3-(dimethylamino)propyl]-3-ethyl-1-{[(2R,4R,7R)-6-(prop-2-en-1-yl)-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraen-4-yl]carbonyl}urea
1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
(8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide
1-[(6-allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea
(8beta)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-6-(prop-2-en-1-yl)ergoline-8-carboxamide
cabergolinum
cabergolina
(8R)-6-allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide
cabergoline
C26H37N5O2
1-ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea
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| xref |
IUPHAR:37
CiteXplore:23110560
Guide To Pharmacology:37
DrugBank:DB00248
CiteXplore:22075008
PubChem Substance:46508571
HMDB:HMDB14393
ChEBI:3286
CASRN:81409-90-7
KEGG DRUG:D00987
CiteXplore:22336848
Drugs.com:http://www.drugs.com/cdi/cabergoline.html
Beilstein:6020775
National Drug Code Directory:49884-673-14
Wikipedia:Cabergoline
ChEMBL:775038
ChemSpider:49452
PubChem Compound:54746
CiteXplore:22740242
Patent:US4526892
Drugs Product Database (DPD):2242471
Wikipedia:http://en.wikipedia.org/wiki/Cabergoline
RxList:http://www.rxlist.com/cgi/generic/cabergoline.htm
Patent:BE888243
KEGG COMPOUND:C08187
CiteXplore:23743769
PharmGKB:PA448708
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| CASRN | 81409-90-7
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| prefixIRI | obo2:CHEBI_3286
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| SMILES |
[H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@H](CN2CC=C)C(=O)N(CCCN(C)C)C(=O)NCC
[H][C@@]12CC3=CNC4=CC=CC(=C34)[C@@]1([H])C[C@H](CN2CC=C)C(=O)N(CCCN(C)C)C(=O)NCC
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| may interact with |
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| DBname | cabergoline
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| InChI | InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1
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| DBBrand |
dostinex
cabaser
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| subClassOf |
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