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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_3216
http://purl.obolibrary.org/obo/CHEBI_3216
|
|---|---|
| Preferred Name | buprenorphine |
| Synonyms |
buprenorphinum
C29H41NO4
17-cyclopropylmethyl-4,5alpha-epoxy-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6-methoxy-6,14-endo-ethanomorphinan-3-ol
(1S,2R,6S,14R,15R,16R)-3-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-3-azahexacyclo[13.2.2.1^{2,8}.0^{1,6}.0^{6,14}.0^{7,12}]icosa-7,9,11-trien-11-ol
2-(N-cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-6alpha-yl)-3,3-dimethyl-2-butanol
(-)-buprenorphine
(5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
Buprenorphine
21-cyclopropyl-7alpha-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine
2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(14R)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11-trien-16-yl]-3,3-dimethyl-2-butanol
buprenorphine
buprenorfina
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | buprenorphine
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|---|---|
| label | buprenorphine
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| DBSynonym |
buprenorfina [inn-spanish]
buprenorphinum [inn-latin]
buprenophine
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| ATCCode |
N02AE01
N07BC01
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| Definition | A morphinane alkaloid that is 7,8-dihydromorphine 6-O-methyl ether in which positions 6 and 14 are joined by a -CH2CH2- bridge, one of the hydrogens of the N-methyl group is substituted by cyclopropyl, and a hydrogen at position 7 is substituted by a 2-hydroxy-3,3-dimethylbutan-2-yl group.
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| altId |
CHEBI:143179
CHEBI:489640
CHEBI:453763
CHEBI:166254
CHEBI:656608
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| has effect |
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| DBSalt | buprenorphine hydrochloride
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| has pharmacological target | |
| inhibits |
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| type | |
| has role | |
| InChIKey | InChIKey=RMRJXGBAOAMLHD-IHFGGWKQSA-N
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| is metabolised by |
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| blocks | |
| AHFScode | 28:08.12
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| Synonym | buprenorphinum
C29H41NO4
17-cyclopropylmethyl-4,5alpha-epoxy-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6-methoxy-6,14-endo-ethanomorphinan-3-ol
(1S,2R,6S,14R,15R,16R)-3-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-3-azahexacyclo[13.2.2.1^{2,8}.0^{1,6}.0^{6,14}.0^{7,12}]icosa-7,9,11-trien-11-ol
2-(N-cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-6alpha-yl)-3,3-dimethyl-2-butanol
(-)-buprenorphine
(5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
Buprenorphine
21-cyclopropyl-7alpha-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine
2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(14R)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11-trien-16-yl]-3,3-dimethyl-2-butanol
buprenorphine
buprenorfina
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| xref |
Drugs.com:http://www.drugs.com/cdi/buprenorphine.html
ChEBI:3216
KEGG DRUG:D07132
ChEMBL:16650985
PubChem Substance:46505782
DrugBank:DB00921
PubChem Compound:40400
Wikipedia:http://en.wikipedia.org/wiki/Buprenorphine
PharmGKB:PA448685
Beilstein:6182863
ChEMBL:17887741
Patent:GB1136214
RxList:http://www.rxlist.com/cgi/generic3/suboxone.htm
ChEMBL:10649968
KEGG COMPOUND:C08007
CASRN:52485-79-7
National Drug Code Directory:12496-0757-1
Patent:US3433791
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| CASRN | 52485-79-7
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| prefixIRI | obo2:CHEBI_3216
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| related with | |
| SMILES |
[H][C@@]1(C[C@]23CC[C@]1(OC)[C@@H]1Oc4c(O)ccc5C[C@H]2N(CC[C@@]31c45)CC1CC1)[C@](C)(O)C(C)(C)C
CO[C@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1CC4=C5C(O[C@@H]2[C@@]35CCN1CC1CC1)=C(O)C=C4
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| may interact with |
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| DBname | buprenorphine
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| InChI | InChI=1S/C29H41NO4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26+,27-,28+,29-/m1/s1
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| DBBrand |
buprenex
probuphine
temgesic
subutex
butrans
buprel
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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