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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/CHEBI_28329
http://purl.obolibrary.org/obo/CHEBI_28329
|
|---|---|
| Preferred Name | trioxsalen |
| Synonyms |
4,5',8-Trimethylpsoralen
Trimethylpsoralen
C14H12O3
trioxysalenum
Trioxsalen
trioxisaleno
4,8,5'-Trimethylpsoralen
2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one
trioxysalen
Trioxysalen
6-hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone
2',4,8-Trimethylpsoralen
trioxysalene
4,7,9-trimethyl-2H-furo[3,2-g]chromen-2-one
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | trioxsalen
|
|---|---|
| label | trioxsalen
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| DBSynonym |
trisoralen
trimethylpsoralen
trioxysalen
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| ATCCode | D05AD01
|
| Definition | 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
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| altId |
CHEBI:1758
CHEBI:20282
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| has pharmacological target | |
| type | |
| has role | |
| InChIKey | InChIKey=FMHHVULEAZTJMA-UHFFFAOYSA-N
|
| Synonym |
4,5',8-Trimethylpsoralen
Trimethylpsoralen
C14H12O3
trioxysalenum
Trioxsalen
trioxisaleno
4,8,5'-Trimethylpsoralen
2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one
trioxysalen
Trioxysalen
6-hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone
2',4,8-Trimethylpsoralen
trioxysalene
4,7,9-trimethyl-2H-furo[3,2-g]chromen-2-one
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|
| xref |
KEGG DRUG:D01034
KEGG COMPOUND:C09314
CASRN:3902-71-4
Wikipedia:Trioxsalen
Beilstein:221723
NIST Chemistry WebBook:3902-71-4
DrugBank:DB04571
ChEMBL:502531
Patent:US3201421
Wikipedia:http://en.wikipedia.org/wiki/Trioxsalen
PharmGKB:PA164747186
Drugs.com:http://www.drugs.com/cons/trioxsalen.html
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| CASRN | 3902-71-4
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| prefixIRI | obo2:CHEBI_28329
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| related with | |
| SMILES |
CC1=CC2=CC3=C(OC(=O)C=C3C)C(C)=C2O1
Cc1cc2cc3c(C)cc(=O)oc3c(C)c2o1
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| DBname | trioxsalen
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| InChI | InChI=1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3
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| subClassOf |
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