The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Id	http://purl.obolibrary.org/obo/CHEBI_110423 http://purl.obolibrary.org/obo/CHEBI_110423
Preferred Name	clodronic acid
Synonyms	dichloromethylene-1,1-diphosphonic acid clodronsaeure clodronate clodronic acid acide clodronique acidum clodronicum (dichloromethanediyl)bis(phosphonic acid) dichloromethylene-1,1-bisphosphonic acid acido clodronico dichloromethylidene diphosphonate (dichloromethylene)bisphosphonic acid (Dichloro-phosphono-methyl)-phosphonic acid CH4Cl2O6P2 [dichloro(phosphono)methyl]phosphonic acid (dichloromethylene)diphosphonic acid See more See less
Type	http://www.w3.org/2002/07/owl#Class

prefLabel	clodronic acid
label	clodronic acid
ATCCode	M05BA02
Definition	Methylene chloride in which both hydrogens are substituted by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.
has effect	http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0001259 http://purl.obolibrary.org/obo/OAE_0000839 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0001260 http://purl.obolibrary.org/obo/OAE_0001369 http://purl.obolibrary.org/obo/OAE_0000545 http://purl.obolibrary.org/obo/OAE_0001049 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0001055 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001105 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001135 http://purl.obolibrary.org/obo/OAE_0001164 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0001366 http://purl.obolibrary.org/obo/OAE_0001364 See more See less
has pharmacological target	http://purl.obolibrary.org/obo/dinto_3913 http://purl.obolibrary.org/obo/dinto_2201 http://purl.obolibrary.org/obo/dinto_4034 http://purl.obolibrary.org/obo/dinto_3465
inhibits	http://purl.obolibrary.org/obo/dinto_3913 http://purl.obolibrary.org/obo/dinto_4034 http://purl.obolibrary.org/obo/dinto_2116 http://purl.obolibrary.org/obo/dinto_3465
type	http://www.w3.org/2002/07/owl#Class
has role	http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_50646
InChIKey	InChIKey=ACSIXWWBWUQEHA-UHFFFAOYSA-N
blocks	http://purl.obolibrary.org/obo/dinto_2201
AHFScode	92:00.00
Synonym	dichloromethylene-1,1-diphosphonic acid clodronsaeure clodronate clodronic acid acide clodronique acidum clodronicum (dichloromethanediyl)bis(phosphonic acid) dichloromethylene-1,1-bisphosphonic acid acido clodronico dichloromethylidene diphosphonate (dichloromethylene)bisphosphonic acid (Dichloro-phosphono-methyl)-phosphonic acid CH4Cl2O6P2 [dichloro(phosphono)methyl]phosphonic acid (dichloromethylene)diphosphonic acid See more See less
xref	PubChem Compound:25419 ChemSpider:23731 PharmGKB:PA10239 ChEMBL:15658873 Drugs Product Database (DPD):1984837 Patent:BE672205 DrugBank:DB00720 Wikipedia:http://en.wikipedia.org/wiki/Clodronate ChEBI:110423 BindingDB:50216172 PubChem Substance:46508646 CASRN:10596-23-3 ChEMBL:7818726 Beilstein:1876367 KEGG DRUG:D03545 ChEMBL:8421279 See more See less
CASRN	10596-23-3
prefixIRI	obo2:CHEBI_110423
SMILES	OP(O)(=O)C(Cl)(Cl)P(O)(O)=O
may interact with	http://purl.obolibrary.org/obo/dinto_DB00893 http://purl.obolibrary.org/obo/dinto_DB00258 http://purl.obolibrary.org/obo/dinto_DB01370 http://purl.obolibrary.org/obo/CHEBI_31794 http://purl.obolibrary.org/obo/dinto_DB00364 http://purl.obolibrary.org/obo/dinto_DB01375 http://purl.obolibrary.org/obo/dinto_DB01378 http://purl.obolibrary.org/obo/dinto_DB01164 http://purl.obolibrary.org/obo/CHEBI_4868 http://purl.obolibrary.org/obo/dinto_DB01373 http://purl.obolibrary.org/obo/dinto_DB01592 See more See less
DBname	clodronate
InChI	InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)
DBBrand	acide clodronique [inn-french] dichloromethanediphosphonic acid ostac acidum clodronicum [inn-latin] clasteon loron acido clodronico [inn-spanish] dichloromethylidene diphosphonate bonefos See more See less
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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