loading...| Preferred Name | zileuton | |
| Synonyms |
N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea 1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea Leutrol Zileuton Zyflo C11H12N2O2S 1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea zileutonum zileuton |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_10112 |
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| binds |
http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2100 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0265 |
|
| CASRN |
111406-87-2 |
|
| DBBrand |
zyflo cr zyflo leutrol |
|
| DBname |
zileuton |
|
| DBSynonym |
zileutonum [inn-latin] |
|
| Definition |
A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma. |
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| has pharmacological target | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_64964 http://purl.obolibrary.org/obo/CHEBI_49159 |
|
| InChI |
InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) |
|
| InChIKey |
InChIKey=MWLSOWXNZPKENC-UHFFFAOYSA-N |
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| inhibits | ||
| is metabolised by |
http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0265 |
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| is substrate of |
http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0265 |
|
| label |
zileuton |
|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_8212 http://purl.obolibrary.org/obo/dinto_DB01303 http://purl.obolibrary.org/obo/dinto_DB01223 http://purl.obolibrary.org/obo/dinto_DB00980 http://purl.obolibrary.org/obo/CHEBI_28177 http://purl.obolibrary.org/obo/dinto_DB06210 |
|
| prefixIRI |
obo2:CHEBI_10112 |
|
| prefLabel |
zileuton |
|
| SMILES |
CC(N(O)C(N)=O)C1=CC2=CC=CC=C2S1 CC(N(O)C(N)=O)c1cc2ccccc2s1 |
|
| Synonym |
N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea 1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea Leutrol Zileuton Zyflo C11H12N2O2S 1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea zileutonum zileuton |
|
| xref |
ChEMBL:109217 KEGG DRUG:D00414 CASRN:111406-87-2 DrugBank:DB00744 Reaxys:4869674 ChEBI:10112 CiteXplore:19645854 Wikipedia:http://en.wikipedia.org/wiki/Zileuton PubChem Compound:60490 CiteXplore:19309543 RxList:http://www.rxlist.com/cgi/generic/zileuton.htm PubChem Substance:46506394 Drugs.com:http://www.drugs.com/cdi/zileuton.html CiteXplore:20436887 National Drug Code Directory:68734-700-10 PharmGKB:PA451955 Wikipedia:Zileuton CiteXplore:20204486 ChemSpider:54531 |
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| subClassOf |