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Drug Interaction Knowledge Base Ontology
Last uploaded:
May 19, 2015
Acronym | DIKB |
Visibility | Public |
Description | An evidence taxonomy for pharmacologic studies that, when combined with a set of inclusion criteria, enable drug experts to specify what their confidence in a drug mechanism assertion would be if it were supported by a specific set of evidence. Boyce R, Collins C, Horn J, Kalet I. Computing with evidence Part I: A drug-mechanism evidence taxonomy oriented toward confidence assignment. J Biomed Inform. 2009 Dec;42(6):979-89. Epub 2009 May 10. PubMed PMID: 19435613; PubMed Central PMCID: PMC2783801. |
Status | Beta |
Format | OWL |
Contact | Richard D Boyce, rdb20@pitt.edu |
Categories | Vocabularies |
Version | Released | Uploaded | Downloads |
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Version 1.6 (Parsed, Indexed, Metrics, Annotator) | 05/18/2015 | 05/19/2015 | OWL | CSV | RDF/XML | Diff |
Version 1.6 (Archived) | 05/18/2015 | 05/18/2015 | OWL | Diff |
The Dug Interaction Knowledge Base ontology. This version is essentially the original version from 2007 with a change to the base IRI to use a PURL (Archived) | 10/14/2011 | 02/09/2013 | OWL | Diff |
1.4 (Archived) | 10/14/2011 | 06/18/2012 | OWL | Diff |
0.2 (Archived) | 10/14/2011 | 10/14/2011 | OWL |
more... |
No views of DIKB available
Classes | 161 |
Individuals | 9 |
Properties | 138 |
Maximum depth | 4 |
Maximum number of children | 25 |
Average number of children | 2 |
Classes with a single child | 26 |
Classes with more than 25 children | 1 |
Classes with no definition | 14 |
Jump to:
Id | http://www.biopax.org/release/biopax-level3.owl#KPrime
http://www.biopax.org/release/biopax-level3.owl#KPrime
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Preferred Name | KPrime |
Definitions |
Definition: The apparent equilibrium constant, K', and associated values.
Usage: Concentrations in the equilibrium constant equation refer to the total concentrations of all forms of particular biochemical reactants. For example, in the equilibrium constant equation for the biochemical reaction in which ATP is hydrolyzed to ADP and inorganic phosphate:
K' = [ADP][P<sub>i</sub>]/[ATP],
The concentration of ATP refers to the total concentration of all of the following species:
[ATP] = [ATP<sup>4-</sup>] + [HATP<sup>3-</sup>] + [H<sub>2</sub>ATP<sup>2-</sup>] + [MgATP<sup>2-</sup>] + [MgHATP<sup>-</sup>] + [Mg<sub>2</sub>ATP].
The apparent equilibrium constant is formally dimensionless, and can be kept so by inclusion of as many of the terms (1 mol/dm<sup>3</sup>) in the numerator or denominator as necessary. It is a function of temperature (T), ionic strength (I), pH, and pMg (pMg = -log<sub>10</sub>[Mg<sup>2+</sup>]). Therefore, these quantities must be specified to be precise, and values for KEQ for biochemical reactions may be represented as 5-tuples of the form (K' T I pH pMg). This property may have multiple values, representing different measurements for K' obtained under the different experimental conditions listed in the 5-tuple. (This definition adapted from EcoCyc)
See http://www.chem.qmul.ac.uk/iubmb/thermod/ for a thermodynamics tutorial.
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
comment | Definition: The apparent equilibrium constant, K', and associated values.
Usage: Concentrations in the equilibrium constant equation refer to the total concentrations of all forms of particular biochemical reactants. For example, in the equilibrium constant equation for the biochemical reaction in which ATP is hydrolyzed to ADP and inorganic phosphate:
K' = [ADP][P<sub>i</sub>]/[ATP],
The concentration of ATP refers to the total concentration of all of the following species:
[ATP] = [ATP<sup>4-</sup>] + [HATP<sup>3-</sup>] + [H<sub>2</sub>ATP<sup>2-</sup>] + [MgATP<sup>2-</sup>] + [MgHATP<sup>-</sup>] + [Mg<sub>2</sub>ATP].
The apparent equilibrium constant is formally dimensionless, and can be kept so by inclusion of as many of the terms (1 mol/dm<sup>3</sup>) in the numerator or denominator as necessary. It is a function of temperature (T), ionic strength (I), pH, and pMg (pMg = -log<sub>10</sub>[Mg<sup>2+</sup>]). Therefore, these quantities must be specified to be precise, and values for KEQ for biochemical reactions may be represented as 5-tuples of the form (K' T I pH pMg). This property may have multiple values, representing different measurements for K' obtained under the different experimental conditions listed in the 5-tuple. (This definition adapted from EcoCyc)
See http://www.chem.qmul.ac.uk/iubmb/thermod/ for a thermodynamics tutorial.
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prefLabel | KPrime
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prefixIRI |
KPrime
bp:KPrime
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subClassOf | |
type | |
disjointWith |
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Step 2: Follow the InstructionsCopy the code below and paste it to your HTML page <iframe frameborder="0" src="/widgets/visualization?ontology=DIKB&class=http%3A%2F%2Fpurl.org%2Fnet%2Fdrug-interaction-knowledge-base%2FDIKB_evidence_ontology.owl%23in_vitro_Protein_Source&apikey=YOUR_API_KEY"></iframe> For more help visit NCBO Widget Wiki |
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Step 2: Follow the InstructionsCopy the code below and paste it to your HTML page <link rel="stylesheet" type="text/css" href="/widgets/jquery.ncbo.tree.css"> <script src="/widgets/jquery.ncbo.tree-2.0.2.js"></script> <div id="widget_tree"></div> var widget_tree = $("#widget_tree").NCBOTree({ apikey: "YOUR_API_KEY", ontology: "DIKB" }); You can also view a detailed demonstration For more help visit NCBO Widget Wiki |