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Drug Interaction Knowledge Base Ontology
Last uploaded:
May 19, 2015
Acronym | DIKB |
Visibility | Public |
Description | An evidence taxonomy for pharmacologic studies that, when combined with a set of inclusion criteria, enable drug experts to specify what their confidence in a drug mechanism assertion would be if it were supported by a specific set of evidence. Boyce R, Collins C, Horn J, Kalet I. Computing with evidence Part I: A drug-mechanism evidence taxonomy oriented toward confidence assignment. J Biomed Inform. 2009 Dec;42(6):979-89. Epub 2009 May 10. PubMed PMID: 19435613; PubMed Central PMCID: PMC2783801. |
Status | Beta |
Format | OWL |
Contact | Richard D Boyce, rdb20@pitt.edu |
Categories | Vocabularies |
Version | Released | Uploaded | Downloads |
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Version 1.6 (Parsed, Indexed, Metrics, Annotator) | 05/18/2015 | 05/19/2015 | OWL | CSV | RDF/XML | Diff |
Version 1.6 (Archived) | 05/18/2015 | 05/18/2015 | OWL | Diff |
The Dug Interaction Knowledge Base ontology. This version is essentially the original version from 2007 with a change to the base IRI to use a PURL (Archived) | 10/14/2011 | 02/09/2013 | OWL | Diff |
1.4 (Archived) | 10/14/2011 | 06/18/2012 | OWL | Diff |
0.2 (Archived) | 10/14/2011 | 10/14/2011 | OWL |
more... |
No views of DIKB available
Classes | 161 |
Individuals | 9 |
Properties | 138 |
Maximum depth | 4 |
Maximum number of children | 25 |
Average number of children | 2 |
Classes with a single child | 26 |
Classes with more than 25 children | 1 |
Classes with no definition | 14 |
Jump to:
Id | http://www.biopax.org/release/biopax-level3.owl#GeneticInteraction
http://www.biopax.org/release/biopax-level3.owl#GeneticInteraction
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Preferred Name | GeneticInteraction |
Definitions |
Definition : Genetic interactions between genes occur when two genetic perturbations (e.g. mutations) have a combined phenotypic effect not caused by either perturbation alone. A gene participant in a genetic interaction represents the gene that is perturbed. Genetic interactions are not physical interactions but logical (AND) relationships. Their physical manifestations can be complex and span an arbitarily long duration.
Rationale: Currently, BioPAX provides a simple definition that can capture most genetic interactions described in the literature. In the future, if required, the definition can be extended to capture other logical relationships and different, participant specific phenotypes.
Example: A synthetic lethal interaction occurs when cell growth is possible without either gene A OR B, but not without both gene A AND B. If you knock out A and B together, the cell will die.
Definition : Genetic interactions between genes occur when two genetic perturbations (e.g. mutations) have a combined phenotypic effect not caused by either perturbation alone. A gene participant in a genetic interaction represents the gene that is perturbed. Genetic interactions are not physical interactios but logical (AND) relationships. Their physical manifestations can be complex and span an arbitarily long duration.
Rationale: Currently, BioPAX provides a simple definition that can capture most genetic interactions described in the literature. In the future, if required, the definition can be extended to capture other logical relationships and different, participant specific phenotypes.
Example: A synthetic lethal interaction occurs when cell growth is possible without either gene A OR B, but not without both gene A AND B. If you knock out A and B together, the cell will die.
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
comment | Definition : Genetic interactions between genes occur when two genetic perturbations (e.g. mutations) have a combined phenotypic effect not caused by either perturbation alone. A gene participant in a genetic interaction represents the gene that is perturbed. Genetic interactions are not physical interactions but logical (AND) relationships. Their physical manifestations can be complex and span an arbitarily long duration.
Rationale: Currently, BioPAX provides a simple definition that can capture most genetic interactions described in the literature. In the future, if required, the definition can be extended to capture other logical relationships and different, participant specific phenotypes.
Example: A synthetic lethal interaction occurs when cell growth is possible without either gene A OR B, but not without both gene A AND B. If you knock out A and B together, the cell will die.
Definition : Genetic interactions between genes occur when two genetic perturbations (e.g. mutations) have a combined phenotypic effect not caused by either perturbation alone. A gene participant in a genetic interaction represents the gene that is perturbed. Genetic interactions are not physical interactios but logical (AND) relationships. Their physical manifestations can be complex and span an arbitarily long duration.
Rationale: Currently, BioPAX provides a simple definition that can capture most genetic interactions described in the literature. In the future, if required, the definition can be extended to capture other logical relationships and different, participant specific phenotypes.
Example: A synthetic lethal interaction occurs when cell growth is possible without either gene A OR B, but not without both gene A AND B. If you knock out A and B together, the cell will die.
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prefLabel | GeneticInteraction
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prefixIRI |
GeneticInteraction
bp:GeneticInteraction
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subClassOf | |
type | |
disjointWith |
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