loading...| Preferred Name | Chronic Myelogenous Leukemia, BCR-ABL1 Positive | |
| Synonyms |
|
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Chronic_Myelogenous_Leukemia |
|
| DEFINITION |
A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and imatinib therapy delay disease progression and prolong overall survival. |
|
| FULL_SYN |
Chronic Myelogenous Leukemia Chronic Myelogenous Leukemias Chronic Myelocytic Leukemia Chronic Granulocytic Leukemia CML Hematopoeitic - Chronic Myelocytic Leukemia (CML) Chronic Myeloid Leukemia CML - Chronic Myelogenous Leukemia BCR-ABL Positive Chronic Myelogenous Leukemia |
|
| isDefinedBy |
A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and imatinib therapy delay disease progression and prolong overall survival. |
|
| label |
Chronic Myelogenous Leukemia, BCR-ABL1 Positive |
|
| prefixIRI |
Thesaurus:Chronic_Myelogenous_Leukemia |
|
| prefLabel |
Chronic Myelogenous Leukemia, BCR-ABL1 Positive |
|
| Synonym |
Chronic Myelogenous Leukemia Chronic Myelogenous Leukemias Chronic Myelocytic Leukemia Chronic Granulocytic Leukemia CML Hematopoeitic - Chronic Myelocytic Leukemia (CML) Chronic Myeloid Leukemia CML - Chronic Myelogenous Leukemia BCR-ABL Positive Chronic Myelogenous Leukemia |
|
| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Common_Hematopoietic_Neoplasm http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Chronic_Myeloproliferative_Disorder http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Myeloid_Leukemia |