approach to accelerate fundamental discovery and translation of that knowledge into effective prevention strategies and new treatments; initiatives funded under the NIH Roadmap address critical roadblocks and knowledge gaps that currently constrain rapid progress in biomedical research; they synergize the work of many NIH Institutes and Centers, and collectively represent a unique effort that no single or group of Institutes or Centers or other entity can do, but are the responsibility of the NIH as a whole; although NIH Roadmap funding began in Fiscal Year 2004, the tag term was not created until FY 2006; for FY 2004 and FY 2005, NIH Roadmap funding is indicated in the title by (RMI); term is indexed on NIH Roadmap Inititive grants exclusively and is only applied at the end of the Fiscal Year by a designated indexer.