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Cell Ontology
Last uploaded:
June 8, 2026
| Id | http://purl.obolibrary.org/obo/GO_0007186
http://purl.obolibrary.org/obo/GO_0007186
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|---|---|
| Preferred Name | G protein-coupled receptor signaling pathway |
| Definitions |
The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
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| Synonyms |
GPCR signalling pathway
G protein coupled receptor protein signalling pathway
G-protein-coupled receptor protein signalling pathway
G-protein coupled receptor protein signal transduction
G protein coupled receptor protein signaling pathway
GPCR signaling pathway
G-protein coupled receptor signalling pathway
G-protein coupled receptor protein signaling pathway
dimeric G-protein coupled receptor signalling pathway
G-protein coupled receptor signaling pathway via GPCR dimer
dimeric G-protein coupled receptor signaling pathway
See more
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|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
|---|---|
| prefLabel | G protein-coupled receptor signaling pathway
|
| label | G protein-coupled receptor signaling pathway
|
| has_exact_synonym |
GPCR signalling pathway
G protein coupled receptor protein signalling pathway
G-protein-coupled receptor protein signalling pathway
G-protein coupled receptor protein signal transduction
G protein coupled receptor protein signaling pathway
GPCR signaling pathway
G-protein coupled receptor signalling pathway
G-protein coupled receptor protein signaling pathway
See more
See less
|
| in_subset | |
| has_obo_namespace | biological_process
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| starts with | |
| has narrow synonym |
dimeric G-protein coupled receptor signalling pathway
G-protein coupled receptor signaling pathway via GPCR dimer
dimeric G-protein coupled receptor signaling pathway
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| notation | GO:0007186
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| type | |
| subClassOf | |
| database_cross_reference |
Reactome:R-HSA-373076
Reactome:R-HSA-388396
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| id | GO:0007186
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