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Cell Ontology
Last uploaded:
February 13, 2025
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| Id | http://purl.obolibrary.org/obo/CL_1000458
http://purl.obolibrary.org/obo/CL_1000458
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|---|---|
| Preferred Name | melanocyte of skin |
| Definitions |
A melanocyte that is part of the skin of body.
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| Synonyms |
skin melanocyte
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A melanocyte that is part of the skin of body. |
|---|---|
| label |
melanocyte of skin
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| prefLabel |
melanocyte of skin
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| description |
Melanocytes of the skin are specialized pigment cells crucial for producing and distributing melanin, the pigment determining skin, in addition to hair and eye color. Located in the basal layer of the epidermis, melanocytes serve as a natural sunscreen, protecting skin cells from harmful UV radiation. Structurally dendritic, they synthesize melanin through melanogenesis, transferring melanosomes to keratinocytes for UV shielding
Beyond pigmentation and UV protection, melanocytes play roles in immune and inflammatory responses. They respond to environmental changes, communicate with skin cell types, and secrete cytokines and growth factors influencing skin homeostasis. Dysregulation may lead to pigment disorders like vitiligo and melasma or contribute to skin cancer, particularly malignant melanoma.
(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
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| database_cross_reference | |
| in_subset | |
| part_of | |
| prefixIRI |
CL:1000458
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| present in taxon | |
| subClassOf | |
| type | |
| has_exact_synonym |
skin melanocyte
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| treeView |
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