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Cell Ontology
Last uploaded:
June 8, 2026
| Id | http://purl.obolibrary.org/obo/CL_0000826
http://purl.obolibrary.org/obo/CL_0000826
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|---|---|
| Preferred Name | pro-B cell |
| Definitions |
Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.
A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs.
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| Synonyms |
progenitor B-cell
pro-B-lymphocyte
progenitor B cell
progenitor B lymphocyte
pro-B lymphocyte
progenitor B-lymphocyte
pro-B-cell
pre-pro B cell
pre-B cell (Philadelphia nomenclature)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs. |
|---|---|
| label | pro-B cell
|
| comment | Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.
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| prefLabel | pro-B cell
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| database_cross_reference |
ZFA:0009349
BTO:0003104
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| in_subset | |
| has_related_synonym | pre-B cell (Philadelphia nomenclature)
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| has part | |
| prefixIRI | CL:0000826
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| subClassOf | |
| develops_from | |
| type | |
| has_broad_synonym | pre-pro B cell
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| has_exact_synonym |
progenitor B-cell
pro-B-lymphocyte
progenitor B cell
progenitor B lymphocyte
pro-B lymphocyte
progenitor B-lymphocyte
pro-B-cell
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