Cell Ontology

Last uploaded: February 13, 2025
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Id http://purl.obolibrary.org/obo/CL_0000771
http://purl.obolibrary.org/obo/CL_0000771
Preferred Name

eosinophil
Definitions
Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive. Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte.
Synonyms
polymorphonuclear leucocyte
polymorphonuclear leukocyte
eosinophilic leucocyte
eosinophilic granulocyte
eosinophilic leukocyte
eosinocyte
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive.
label
eosinophil
comment
Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte.
prefLabel
eosinophil
database_cross_reference
CALOHA:TS-0279
MESH:D004804
BTO:0000399
FMA:62861
in_subset
has plasma membrane part
has part
prefixIRI
CL:0000771
present in taxon
subClassOf
overlaps
type
has_broad_synonym
polymorphonuclear leucocyte
polymorphonuclear leukocyte
has_exact_synonym
eosinophilic leucocyte
eosinophilic granulocyte
eosinophilic leukocyte
eosinocyte
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