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Cell Ontology
Last uploaded:
June 8, 2026
| Id | http://purl.obolibrary.org/obo/CL_0000557
http://purl.obolibrary.org/obo/CL_0000557
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|---|---|
| Preferred Name | granulocyte monocyte progenitor cell |
| Definitions |
Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1.
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| Synonyms |
colony forming unit granulocyte macrophage
granulocyte-macrophage progenitor
granulocyte/monocyte progenitor
granulocyte/monocyte precursor
CFU-C , Colony forming unit in culture
CFU-GM
GMP
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. |
|---|---|
| prefLabel | granulocyte monocyte progenitor cell
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| label | granulocyte monocyte progenitor cell
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| description | Granulocyte monocyte progenitor cells (GMP cells), originating from hematopoietic stem cells in the bone marrow, are a critical intermediate in myeloid cell development. Positioned at a key differentiation juncture, these cells exhibit bidirectional potential, giving rise to both granulocyte and monocyte lineages.
Their primary role is to generate mature granulocytes and monocytes, essential components of the body's innate immunity and inflammatory responses. Granulocytes, such as neutrophils, eosinophils, and basophils, contribute to the first line of defense against infections by migrating to the infection site and phagocytosing pathogens. Monocytes can differentiate into macrophages or dendritic cells, playing diverse roles in immune responses.
(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)
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| comment | Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
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| lacks_part | |
| prefixIRI | CL:0000557
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| has_exact_synonym |
colony forming unit granulocyte macrophage
granulocyte-macrophage progenitor
granulocyte/monocyte progenitor
granulocyte/monocyte precursor
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| has_related_synonym |
CFU-GM
GMP
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| see also | |
| has_broad_synonym | CFU-C , Colony forming unit in culture
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| in_subset | |
| capable of | |
| has part | |
| type | |
| subClassOf | |
| has plasma membrane part | |
| database_cross_reference | ZFA:0009251
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