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Cell Ontology
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April 10, 2025
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Id | http://purl.obolibrary.org/obo/CL_0000453
http://purl.obolibrary.org/obo/CL_0000453
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Preferred Name | Langerhans cell |
Definitions |
Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus.
Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis.
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Synonyms |
LC
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
definition | Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus. |
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label | Langerhans cell
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comment | Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis.
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prefLabel | Langerhans cell
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database_cross_reference |
MESH:D007801
CALOHA:TS-2375
BTO:0000705
FMA:63072
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in_subset | |
has plasma membrane part | |
has part | |
prefixIRI | CL:0000453
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capable of part of | |
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type | |
has_exact_synonym | LC
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