Cell Ontology

Last uploaded: April 10, 2025
Id http://purl.obolibrary.org/obo/CL_0000453
http://purl.obolibrary.org/obo/CL_0000453
Preferred Name

Langerhans cell

Definitions
Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus. Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis.
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LC
Type http://www.w3.org/2002/07/owl#Class
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