Coronavirus Infectious Disease Ontology

Last uploaded: February 16, 2024
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Preferred Name

AKT kinase
Synonyms

PKB

serine-threonine kinase Akt

AKT
Definitions

A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites. Category=family.
ID

http://purl.obolibrary.org/obo/PR_000029189
comment

Category=family.
alternative term

PKB

serine-threonine kinase Akt

AKT
has exact synonym

serine-threonine kinase Akt

AKT
has_broad_synonym

PKB
has_obo_namespace

protein
id

PR:000029189
imported from

http://purl.obolibrary.org/obo/pr.owl
label

AKT kinase
notation

PR:000029189
prefLabel

AKT kinase
textual definition

A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites.
subClassOf

http://purl.obolibrary.org/obo/PR_000000001
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