Link to this page
Coronavirus Infectious Disease Ontology
Last uploaded:
February 16, 2024
Jump to:
| Id | http://purl.obolibrary.org/obo/PR_000001094
http://purl.obolibrary.org/obo/PR_000001094
|
|---|---|
| Preferred Name | rhodopsin-like G-protein coupled receptor |
| Definitions |
A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions.
Category=family. Classification based on GRAFS system. [PMID:12761335]
|
| Synonyms |
class 1 G-protein coupled receptor
fam:rhodopsin
class A G-protein coupled receptor
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
rhodopsin-like G-protein coupled receptor
|
|---|---|
| comment |
Category=family. Classification based on GRAFS system. [PMID:12761335]
|
| prefLabel |
rhodopsin-like G-protein coupled receptor
|
| database_cross_reference |
IUPHAR:GPCRListForward?class=A
PIRSF:PIRSF800006
|
| notation |
PR:000001094
|
| id |
PR:000001094
|
| has_obo_namespace |
protein
|
| textual definition |
A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions.
|
| subClassOf | |
| imported from | |
| type | |
| has exact synonym |
class 1 G-protein coupled receptor
fam:rhodopsin
class A G-protein coupled receptor
|
| alternative term |
class 1 G-protein coupled receptor
fam:rhodopsin
class A G-protein coupled receptor
|
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |