Coronavirus Infectious Disease Ontology

Last uploaded: February 16, 2024
Id http://purl.obolibrary.org/obo/PR_000001094
http://purl.obolibrary.org/obo/PR_000001094
Preferred Name

rhodopsin-like G-protein coupled receptor
Definitions
Category=family. Classification based on GRAFS system. [PMID:12761335] A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions.
Synonyms
class 1 G-protein coupled receptor
fam:rhodopsin
class A G-protein coupled receptor
Type http://www.w3.org/2002/07/owl#Class

All Properties

prefLabel
rhodopsin-like G-protein coupled receptor
label
rhodopsin-like G-protein coupled receptor
comment
Category=family. Classification based on GRAFS system. [PMID:12761335]
has exact synonym
class 1 G-protein coupled receptor
fam:rhodopsin
class A G-protein coupled receptor
textual definition
A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions.
has_obo_namespace
protein
notation
PR:000001094
imported from
type
subClassOf
database_cross_reference
IUPHAR:GPCRListForward?class=A
PIRSF:PIRSF800006
id
PR:000001094
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