Coronavirus Infectious Disease Ontology

Last uploaded: February 16, 2024
Jump to:
loading...
Preferred Name

TGF-beta-like cystine-knot cytokine
Synonyms

TGF-beta superfamily
Definitions

A protein with a core domain composition consisting of a signal peptide, a variable propeptide region and a Transforming growth factor beta like domain (Pfam:PF00019), which is a cystine-knot domain containing four conserved beta strands, S1-S4, which form two antiparallel beta sheets (SI-S2 and S3-S4) interconnected by three disulfide bridges in a knot-like topology. Cystines [II-V] and [III-VI] form a ring through which the remaining disulfide bond (Cys[I-IV]) penetrates. Insertion of different variable regions into this common motif has given rise to various subclasses of the growth factor cystine-knot domain. Category=family.
ID

http://purl.obolibrary.org/obo/PR_000000008
comment

Category=family.
alternative term

TGF-beta superfamily
database_cross_reference

PIRSF:PIRSF800009
has_obo_namespace

protein
has_related_synonym

TGF-beta superfamily
id

PR:000000008
imported from

http://purl.obolibrary.org/obo/pr.owl
label

TGF-beta-like cystine-knot cytokine
notation

PR:000000008
prefLabel

TGF-beta-like cystine-knot cytokine
textual definition

A protein with a core domain composition consisting of a signal peptide, a variable propeptide region and a Transforming growth factor beta like domain (Pfam:PF00019), which is a cystine-knot domain containing four conserved beta strands, S1-S4, which form two antiparallel beta sheets (SI-S2 and S3-S4) interconnected by three disulfide bridges in a knot-like topology. Cystines [II-V] and [III-VI] form a ring through which the remaining disulfide bond (Cys[I-IV]) penetrates. Insertion of different variable regions into this common motif has given rise to various subclasses of the growth factor cystine-knot domain.
subClassOf

http://purl.obolibrary.org/obo/PR_000000001
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display