Coronavirus Infectious Disease Ontology

Last uploaded: February 16, 2024

Preferred Name	Lovastatin [Chemical/Ingredient]
Synonyms
ID	http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000007106
code	C24564
Display_Name	Lovastatin
imported from	http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl
label	Lovastatin [Chemical/Ingredient]
MeSH_CUI	M0012707
MeSH_Definition	A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
MeSH_DUI	D008148
MeSH_Name	Lovastatin
NUI	N0000007106
prefixIRI	NDF-RT:N0000007106
prefLabel	Lovastatin [Chemical/Ingredient]
RxNorm_CUI	6472
RxNorm_Name	Lovastatin
Synonym	6-Methylcompactin Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R),3alpha,7beta,8beta(2S,4S*),8abeta))- Monacolin K Mevinolin
UMLS_CUI	C0024027
subClassOf	http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000007809

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Mapping To	Ontology	Source
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000007106	INBANCIDO	SAME_URI
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000007106	ODAE	SAME_URI
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000007106	OCVDAE	SAME_URI
http://purl.bioontology.org/ontology/NDFRT/N0000007106	NDFRT	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000007106	INBANCIDO	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000007106	ODAE	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000007106	OCVDAE	LOOM