Preferred Name |
prednisone |
|
Synonyms |
17,21-dihydroxypregna-1,4-diene-3,11,20-trione Dehydrocortisone prednisonum 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione prednisona 1,2-Dehydrocortisone 1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione prednisone prednison |
|
Definitions |
A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid. |
|
ID |
http://purl.obolibrary.org/obo/CHEBI_8382 |
|
charge |
0 |
|
database_cross_reference |
Drug_Central:2253 Patent:US2579479 PMID:15859934 KEGG:C07370 Patent:US2897216 Beilstein:2065301 Reaxys:2065301 PMID:10438974 PMID:23395281 DrugBank:DB00635 Wikipedia:Prednisone PMID:23093541 CAS:53-03-2 Patent:US3134718 Patent:US2837464 PMID:18971570 |
|
definition |
A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid. |
|
formula |
C21H26O5 |
|
has role |
http://purl.obolibrary.org/obo/CHEBI_35705 http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_37962 |
|
has_exact_synonym |
17,21-dihydroxypregna-1,4-diene-3,11,20-trione |
|
has_obo_namespace |
chebi_ontology |
|
has_related_synonym |
Dehydrocortisone prednisonum 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione prednisona 1,2-Dehydrocortisone 1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione prednisone prednison |
|
id |
CHEBI:8382 |
|
in_subset | ||
inchi |
InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 |
|
inchikey |
XOFYZVNMUHMLCC-ZPOLXVRWSA-N |
|
label |
prednisone |
|
mass |
358.42810 |
|
monoisotopicmass |
358.17802 |
|
notation |
CHEBI:8382 |
|
prefLabel |
prednisone |
|
smiles |
[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])C(=O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO |
|
treeView |
http://purl.obolibrary.org/obo/CHEBI_139590 http://purl.obolibrary.org/obo/CHEBI_139592 http://purl.obolibrary.org/obo/CHEBI_36885 http://purl.obolibrary.org/obo/CHEBI_24261 http://purl.obolibrary.org/obo/CHEBI_77166 http://purl.obolibrary.org/obo/CHEBI_35344 http://purl.obolibrary.org/obo/CHEBI_47787 |
|
subClassOf |
http://purl.obolibrary.org/obo/CHEBI_139590 http://purl.obolibrary.org/obo/CHEBI_139592 http://purl.obolibrary.org/obo/CHEBI_36885 http://purl.obolibrary.org/obo/CHEBI_24261 http://purl.obolibrary.org/obo/CHEBI_77166 http://purl.obolibrary.org/obo/CHEBI_35344 http://purl.obolibrary.org/obo/CHEBI_47787 |