loading...| Preferred Name |
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| Synonyms |
mandibular gland submandibular salivary gland mandibular salivary gland submaxillary gland maxillary gland glandula submandibularis |
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| Definitions |
lobular, sexually dimorphic in mouse Either of the paired compound tubuloalveolar (aka tubuloacinar) major salivary glands composed of both serous and mucous secretory cells and situated beneath the mandible. |
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| ID |
http://purl.obolibrary.org/obo/UBERON_0001736 |
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| comment |
lobular, sexually dimorphic in mouse |
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| database_cross_reference |
Wikipedia:Submandibular_gland MESH:D013363 NCIT:C12233 VHOG:0000364 BTO:0001316 EMAPA:18812 SCTID:181235001 CALOHA:TS-0988 EFO:0001387 UMLS:C0038556 EV:0100061 FMA:55093 GAID:942 MA:0001589 |
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| definition |
Either of the paired compound tubuloalveolar (aka tubuloacinar) major salivary glands composed of both serous and mucous secretory cells and situated beneath the mandible. |
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| depiction |
http://upload.wikimedia.org/wikipedia/commons/5/51/Illu_quiz_hn_02.jpg |
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| external_definition |
Either of two major salivary glands situated in the neck near the lower edge of each side of the mandible and emptying into the submandibular duct. [TFD][VHOG] |
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| has_exact_synonym |
mandibular gland submandibular salivary gland mandibular salivary gland |
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| has_obo_namespace |
uberon |
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| has_related_synonym |
submaxillary gland maxillary gland glandula submandibularis |
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| homology_notes |
The most common oral glands in mammals are the salivary glands. There are usually three primary pairs of salivary glands, named for their approximate positions: mandibular (submandibular or submaxillary), sublingual, and parotid.[well established][VHOG] |
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| id |
UBERON:0001736 |
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| in_subset |
http://purl.obolibrary.org/obo/uberon/core#efo_slim |
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| label |
submandibular gland |
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| notation |
UBERON:0001736 |
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| taxon_notes |
In humans, they account for 70% of the salivary volume and weigh about 15 grams. [WP,unvetted] In mouse, multilobed and lobulated, on the ventral midline of the neck in mice, submandibular gland development initiates as a thickening of the oral epithelium; around E12 an initial (single) epithelial bud on a stalk grows into a condensing neural crest-derived mesenchyme; clefts in the epithelium result in 3-5 epithelial buds at E13.5, and branching morphogenesis occurs with continued proliferation, successive rounds of cleft formation, duct elongation, and duct lumen formation, so that by E14 the gland is highly branched (multi-lobed); functional differentiation, with the appearance of proacinar cells and secretory products begins after E15 and continues to birth; acinar differentiation continues postnatally with final differentiation of the granular convoluted tubules at puberty[MGI:anna] |
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| UBPROP_0000011 |
The submandibular is the first major salivary gland to develop in the embryo, followed by the neighbouring sublingual and then the parotid.[PMID:17336109] |
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| UBPROP_0000013 |
The term submandibular as used in humans, is incorrect due the difference in topography of these structures[http://www.avdc.org] |
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| subClassOf |