Cell Culture Ontology

Last uploaded: July 23, 2014
Preferred Name

Synonyms

gullet

oesophagus

Definitions

Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993).

ID

http://purl.obolibrary.org/obo/UBERON_0001043

database_cross_reference

SCTID:181245004

UMLS:C0014876

MESH:D004947

MIAA:0000048

EMAPA:16833

MAT:0000048

CALOHA:TS-0700

galen:Esophagus

ANISEED:1235301

NCIT:C12389

VHOG:0000450

BTO:0000959

XAO:0000127

TAO:0000204

ZFA:0000204

EFO:0000835

AAO:0000145

EHDAA2:0001285

Wikipedia:Esophagus

EHDAA:2937

EV:0100069

FMA:7131

GAID:291

MA:0000352

definition

Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993).

depiction

http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg

external_definition

Anterior end of the alimentary canal lined with smooth muscle. Bounded anteriorly by a constriction in the pharynx. Bounded posteriorly by and increase in circular and/or longitudinal smooth muscle associated with the stomach.[AAO]

external_ontology_notes

esophagus NOT part of gut in MA. part of gut in ZFA. part_of gut (via UGIT) in FMA. Consider splitting. Interspecies: The human oesophagus is 25 cm long and has a diameter of ca. 2 cm. Only little information was found on the oesophagus in rat, rabbit and pig. The oesophagus of rat (75 x 2 mm) and rabbit has no mucous glands and the cardia of the stomach has a well-developed sphincter, which prevents them from vomiting (Hebel and Stromberg, 1988; Manning et al., 1994). Morphologically the oesophagus is similar in man and pig; both are omnivores and have a non-keratinised epithelium, submucous glands and similar membrane enzymes. Like in humans, pigs can suffer from reflux oesophagitis and stress ulceration of the oesophagus. The pig oesophagus may therefore be a good model for investigation compared to the human oesophagus (Christie et al., 1995)

has_exact_synonym

gullet

oesophagus

has_obo_namespace

uberon

has_relational_adjective

esophageal

homology_notes

The few structural specializations in (adult lampreys) pharynx include complex valves on the external gill openings that direct the tidal flow, and the division of the ancestral pharynx into an oesophagus and a respiratory pharynx.[well established][VHOG]

id

UBERON:0001043

in_subset

http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas

http://purl.obolibrary.org/obo/uberon/core#efo_slim

http://purl.obolibrary.org/obo/uberon/core#organ_slim

http://purl.obolibrary.org/obo/uberon/core#vertebrate_core

http://purl.obolibrary.org/obo/uberon/core#major_organ

http://purl.obolibrary.org/obo/uberon/core#pheno_slim

http://purl.obolibrary.org/obo/uberon/core#uberon_slim

label

esophagus

notation

UBERON:0001043

part_of

http://purl.obolibrary.org/obo/UBERON_0004908

http://purl.obolibrary.org/obo/UBERON_0000467

http://purl.obolibrary.org/obo/UBERON_0002100

http://purl.obolibrary.org/obo/UBERON_0001007

http://purl.obolibrary.org/obo/UBERON_0000915

RO_0002175

http://purl.obolibrary.org/obo/NCBITaxon_9606

treeView

http://purl.obolibrary.org/obo/UBERON_0004908

http://purl.obolibrary.org/obo/UBERON_0000467

http://purl.obolibrary.org/obo/UBERON_0002100

http://purl.obolibrary.org/obo/UBERON_0001007

http://purl.obolibrary.org/obo/UBERON_0000915

subClassOf

http://purl.obolibrary.org/obo/UBERON_0000061

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