loading...| Preferred Name |
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| Synonyms |
endocrine system systema endocrinum endocrine glandular system |
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| Definitions |
Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity. |
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| ID |
http://purl.obolibrary.org/obo/UBERON_0000949 |
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| database_cross_reference |
FBbt:00005068 CALOHA:TS-1301 UMLS:C0014136 ZFA:0001158 MESH:D004703 EMAPA:35306 SCTID:278876000 NCIT:C12705 AAO:0010279 VHOG:0000098 TAO:0001158 XAO:0000158 Wikipedia:Endocrine_system EHDAA2:0002224 EFO:0002969 EV:0100128 FMA:9668 GAID:439 MA:0000012 |
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| definition |
Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity. |
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| external_definition |
Anatomical system containing glands which regulates bodily functions though the secretion of hormones.[AAO] |
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| has_exact_synonym |
endocrine system systema endocrinum endocrine glandular system |
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| has_obo_namespace |
uberon |
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| has_relational_adjective |
endocrine |
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| homology_notes |
Multicellular organisms have complex endocrine systems, allowing responses to environmental stimuli, regulation of development, reproduction, and homeostasis. Nuclear receptors (NRs), a metazoan-specific family of ligand-activated transcription factors, play central roles in endocrine responses, as intermediates between signaling molecules and target genes. The NR family includes ligand-bound and orphan receptors, that is, receptors with no known ligand or for which there is no ligand Pocket. Understanding NR evolution has been further improved by comparison of several completed genomes, particularly those of deuterostomes and ecdysozoans. In contrast, evolution of NR ligands is still much debated. One hypothesis proposes that several independent gains and losses of ligand-binding ability in NRs occurred in protostomes and deuterostomes. A second hypothesis, pertaining to the NR3 subfamily (vertebrate steroid hormone receptors and estrogen related receptor), proposes that before the divergence of protostomes and deuterostomes, there was an ancestral steroid receptor (AncSR) that was ligand-activated and that orphan receptors secondarily lost the ability to bind a ligand. (...) Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages (...).[well established][VHOG] |
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| id |
UBERON:0000949 |
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| in_subset |
http://purl.obolibrary.org/obo/uberon/core#efo_slim http://purl.obolibrary.org/obo/uberon/core#vertebrate_core |
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| label |
endocrine system |
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| notation |
UBERON:0000949 |
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| disjointWith |
http://purl.obolibrary.org/obo/UBERON_0001033 http://purl.obolibrary.org/obo/UBERON_0002294 http://purl.obolibrary.org/obo/UBERON_0002423 http://purl.obolibrary.org/obo/UBERON_0000990 http://purl.obolibrary.org/obo/UBERON_0001434 http://purl.obolibrary.org/obo/UBERON_0001016 http://purl.obolibrary.org/obo/UBERON_0002390 http://purl.obolibrary.org/obo/UBERON_0001009 http://purl.obolibrary.org/obo/UBERON_0001007 http://purl.obolibrary.org/obo/UBERON_0001004 http://purl.obolibrary.org/obo/UBERON_0002405 |
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| subClassOf |