Cell Culture Ontology

Last uploaded: July 23, 2014
Preferred Name

Synonyms

6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine

6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine

6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine

Imuran (TN)

Definitions

A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

ID

http://purl.obolibrary.org/obo/CHEBI_2948

charge

0

database_cross_reference

SNOMEDCT:372574004

ChemIDplus:446-86-6

KEGG DRUG:446-86-6

KEGG DRUG:D00238

ChEMBL:531141

MeSH:D001379

SNOMEDCT:111165009

NCIt:C290

PMID:9345422

PMID:16397313

PMID:9273463

PMID:19243907

PMID:25248004

PMID:28166217

PMID:15199672

Wikipedia:Azathioprine

PMID:8738760

PMID:17970886

PMID:18336531

PMID:20080917

PMID:11064448

Reaxys:1225351

PMID:25641386

CAS:446-86-6

KEGG:C06837

PMID:15476481

PMID:25314066

PMID:18008354

KEGG:D00238

PMID:25440430

PMID:15973722

PMID:17381669

PMID:16764353

PMID:25443086

PMID:25581826

PMID:16344342

PMID:16954801

Drug_Central:269

PMID:15628319

DrugBank:DB00993

definition

A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

formula

C9H7N7O2S

has_exact_synonym

6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine

has_obo_namespace

chebi_ontology

has_related_synonym

6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine

6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine

Imuran (TN)

has_role

http://purl.obolibrary.org/obo/CHEBI_35610

http://purl.obolibrary.org/obo/CHEBI_35221

id

CHEBI:2948

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13)

inchikey

LMEKQMALGUDUQG-UHFFFAOYSA-N

label

azathioprine

mass

277.26386

monoisotopicmass

277.03819

notation

CHEBI:2948

smiles

Cn1cnc(c1Sc1ncnc2nc[nH]c12)[N+]([O-])=O

subClassOf

http://purl.obolibrary.org/obo/CHEBI_35666

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