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Cell Culture Ontology
Last uploaded:
July 23, 2014
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| Preferred Name | peginterferon alfa-2a | |
| Synonyms |
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| Definitions |
A covalent conjugate of recombinant interferon alfa, subtype 2a, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha-2a protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha-2a, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. |
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| ID |
http://www.ebi.ac.uk/efo/EFO_0010102 |
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| database_cross_reference |
NCIt:C33987
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| definition |
A covalent conjugate of recombinant interferon alfa, subtype 2a, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha-2a protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha-2a, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response.
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| has characteristic | ||
| has_role | ||
| label |
peginterferon alfa-2a
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| preferred label |
peginterferon alfa-2a
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| prefixIRI |
efo:EFO_0010102
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| prefLabel |
peginterferon alfa-2a
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| subClassOf |
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